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GI Bleed

GI Bleed. Hossam H assan Emergency Department. GI Bleeding. Maybe classified into: Upper GI bleeding (proximal to DJ flexure) Variceal bleeding Non-variceal bleeding Lower GI bleeding (distal to DJ flexure) Upper GI bleeding 4x more common than lower GI bleeding

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GI Bleed

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  1. GI Bleed HossamHassan Emergency Department

  2. GI Bleeding Maybe classified into: • Upper GI bleeding (proximal to DJ flexure) • Variceal bleeding • Non-variceal bleeding • Lower GI bleeding (distal to DJ flexure) • Upper GI bleeding 4x more common than lower GI bleeding • Emergency resuscitation same for upper and lower GI bleeds

  3. Emegency Resuscitation Takes priority over determining the diagnosis/cause • ABC • Oxygen: 15L Non-rebreath mask • 2 large bore cannulae into both ante-cubital fossae • Take bloods at same time for FBC, U&E, LFT, Clotting, X match 6Units • Catheterise

  4. IVF initially then blood as soon as available (depending on urgency: O-, Group specific, fully X-matched) • Monitor response to resuscitation frequently (HR, BP, urine output, level of consciousness, peripheral temperature, CRT)

  5. Stop anti-coagulants and correct any clotting derrangement • NG tube and aspiration (will help differentiate upper from lower GI bleed) • Organise definitive treatment (endoscopic/radiological/surgical

  6. Estimating Degree of Blood Loss • RR, HR, and BP can be used to estimate degree of blood loss/hypovolaemia

  7. History and Examination • Aim of history and examination is 3 fold • 1. Identify likely source – upper vs lower – and potential cause • 2. Determine severity of bleeding • 3. Identify precipitants (e.g. Drugs)

  8. History in patients with GI bleeding • Duration, frequency, and volume of bleeding (indicate severity of bleeding) • Nature of bleeding: will point to source • Haematemesis (fresh or coffee ground)/melaena suggest upper GI bleed. (Note a very brisk upper GI bleed can present with dark or bright red blood PR).

  9. History in patients with GI bleeding • PR Dark red blood suggests colon • PR Bright red blood suggests rectum, anus • If PR bleeding, is blood being passed alone or with bowel opening (if alone suggests heavier bleeding) • If with bowel opening is blood mixed with the stool (colonic), coating the stool (colonic/rectal), in the toilet water (anal), on wiping (anal)

  10. History in patients with GI bleeding • Ask about associated upper or lower GI symptoms that may point to underlying cause • E.g. Upper abdominal pain/dyspeptic symptoms suggest upper GI cause such as peptic ulcer • E.g. 2. lower abdo pain, bowel symptoms such as diarrhoea or a background of change in bowel habit suggest lower GI cause e.g. Colitis, cancer • Previous episodes of bleeding and cause

  11. History in patients with GI bleeding • PMH • History of any diseases that can result in GI bleeding, e.g. Peptic ulcer disease, diverticular disease, liver disease/cirrhosis • Bleeding disorders e.g. haemophilia

  12. History in patients with GI bleeding • DH • Anti-platelets or anti-coagulants can exacerbate bleeding • NSAIDs and steroids may point to PUD • SH • Alcoholics at risk of liver disease and possible variceal bleeding as a result • Smokers at risk of peptic ulcer disease

  13. Examination in patients with GI bleeding • Reduced level of consiousness • Pale and clammy • Cool peripheries • Tachcardic and thready pulse • Hypotensive with narrow pulse pressure • Tenderness on abdominal examination may point to • underlying cause e.g. Epigastric  peptic ulcer

  14. Examination in patients with GI bleeding • Stigmata of chronic liver disease (palmer erythema, leukonychia, dupuytrens contracture, liver flap, jaundice, spider naevi, gynacomastia, shifting dullness/ascites) • Digital rectal examination may reveal melaena, dark red blood, bright red blood

  15. Upper GI bleed

  16. Upper GI bleed • Upper GI bleeding refers to bleeding from oesophagus, stomach, duodenum (i.e. Proximal to ligamnet of treitz)

  17. Presentation • Acute Upper GI bleeding presents as: • Haematemesis (vomiting of fresh blood) • Coffee ground vomit (partially digested blood) • Melaena (black tarry stools PR) • If bleeding very brisk and severe then can present with red blood PR! • If bleeding very slow and occult then can present with iron deficiency anaemia

  18. Causes

  19. Risk Stratification: Rockall Score • Identifies patients at risk of adverse outcome following acute upper GI bleed • Score <3 carries good prognosis • Score >8 carries high risk of mortality

  20. Management (Non-variceal) • Emergency resuscitation as already described • Endoscopy • Urgent OGD (within 24hrs) – diagnostic and therepeutic • Treatment administered if active bleeding, visible vessel, adherent blood clot • Treatment options include injection (adrenaline), coagulation, clipping • If re-bleeds then arrange urgent repeat OGD • analysis)

  21. Pharmacology • PPI (infusion) – pH >6 stabilises clots and reduces risk of re-bleeding following endoscopic haemostasis • Tranexamic acid (anti-fibrinolytic) – maybe of benefit (more studies needed) • If H pylori positive then for eradication therapy • Stop NSAIDs/aspirin/clopidogrel/warfarin/steroids if safe to do so (risk:benefit

  22. Management (Non-variceal) • Surgery • Reserved for patients with failed medical management (ongoing bleeding despite 2x OGD) • Nature of operation depends on cause of bleeding (most commonly performed in context of bleeding peptic ulcer: DU>GU) • E.g. Under-running of ulcer (bleeding DU), wedge excision of bleeding lesion (e.g. GU), partial/total gastrectomy (malignancy)

  23. Variceal Bleeds • Suspect if upper GI bleed in patient with history of chronic liver disease/cirrhosis or stigmata on clinical examination • Liver Cirrhosis results in portal hypertension and development of porto-systemic anastamosis (opening or dilatation of pre-existing vascular channels connecting portal and systemic circulations)

  24. Sites of porto-systemic anastamosis include: • Oesophagus (P= eosophageal branch of L gastric v, S= oesophageal branch of azygous v) • Umbilicus (P= para-umbilical v, S= infeior epigastric v) • Retroperitoneal (P= right/middle/left colic v, S= renal/supra-renal/gonadal v) • Rectal (P= superior rectal v, S= middle/inferior rectal v) • Furthermore, clotting derrangement in those with chronic liver disease can worsen bleeding

  25. Management of Variceal bleeds • Emergency resuscitation as already described • Drugs • Somatostatin/octreotide – vasoconstricts splanchnic circulation and reduces pressure in portal system • Terlipressin – vasoconstricts splanchnic circulation and reduces pressure in portal system • Propanolol – used only in context of primary prevention (in those found to have varices to reduce risk of first bleed)

  26. Endoscopy • Band ligation • Injection sclerotherapy • Balloon tamponade – sengstaken-blakemore tube • Rarely used now and usually only as temporary measure if failed endoscopic management

  27. Radiological procedure – used if failed medical/endoscopic Mx • Selective catheterisation and embolisation of vessels feeding the varices • TIPSS procedure: transjugular intrahepatic porto-systemic shunt • shunt between hepatic vein and portal vein branch to reduce portal pressure and bleeding from varices): performed if failed medical and endoscopic management • Can worsen hepatic encephalopathy

  28. Surgical • Surgical porto-systemic shunts (often spleno-renal) • Liver transplantation (patients often given TIPP/surgical shunt whilst awaiting this)

  29. TIPSS Sengstaken-Blakemore Tube

  30. Surgical porto-systemic shunt (spleno-renal shunt)

  31. Variceal Bleed: Prognosis • Prognosis closely related to severity of underlying chronic liver disease (Childs-Pugh grading) • Child-Pugh classification grades severity of liver disease into A,B,C based on degree of ascites, encephalopathy, bilirubin, albumin, INR • Mortality 32% Childs A, 46% Childs B, 79% Childs C

  32. Lower GI Bleed

  33. Lower GI bleeding • Lower GI bleed refers to bleeding arising distal to the ligament of Treitz (DJ flexure) • Although this includes jejunum and ileum bleeding from these sites is rare (<5%) • Vast majority of lower GI bleeding arises from colon/rectum/anus

  34. Presentation • Lower GI bleeding presents as: • Dark red blood PR – more proximal bleeding point (e.g. Distal small bowel, colon) • Bright red blood PR – more distal bleeding point (e.g. rectum, anus) • PR blood maybe: • mixed or separate from the stool • If separate from the stool it maybe noticed in the toilet water or on wiping • Passed with motion or alone

  35. If blood mixed with stool (as oppose to separate from it) suggests more proximal bleeding • If bleeding very slow and occult then can present with iron deficiency anaemia

  36. Causes

  37. Management • Emergency resuscitation as already described • Pharmacological • Stop NSAIDS/anti-platelets/anti-coagulants if safe • Tranexamic acid • Endoscopic • OGD (15% of patients with severe acute PR bleeding will have an upper GI source!) • Colonoscopy – diagnostic and therepeutic (injection, diathermy, clipping)

  38. Management • Radiological • CT angiogram – diagnostic only (non-invasive) • Determines site and cause of bleeding • Mesenteric Angiogram – diagnostic and therepeutic (but invasive) • Determines site of bleeding and allows embolisation of bleeding vessel • Can result in colonic ischaemia • Nuclear Scintigraphy – technetium labelled red blood cells: diagnostic only • Determines site of bleeding only (not cause)

  39. Management • Surgical – Last resort in management as very difficult to determine bleeding point at laparotomy • Segmental colectomy – where site of bleeding is known • Subtotal colectomy – where site of bleeding unclear • Beware of small bowel bleeding – always embarassing when bleeding continues after large bowel removed!

  40. Management Flow Chart for Severe lower GI bleeding Resuscitate OGD (to exclude upper GI cause for severe PR bleeding) Colonoscopy (to identify site and cause of bleeding and to treat bleeding by injection/diathermy/clipping) – often unsuccesful as blood obscures views CT angiogram (to identify site and cause of bleeding) Mesenteric angiogram (to identify site of bleeding and treat bleeding by embolisation of vessel) Surgery

  41. Management • As 85% of lower GI bleeds will settle spontaneously the interventions mentioned on previous slide are reserved for: • Severe/Life threatening bleeds • In the 85% where bleeding settles spontaneously OPD investigation is required to determine underlying cause: • Endoscopy: flexible sigmoidoscopy, colonoscopy • Barium enema

  42. The End Questions

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