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BELLWORK. Name the following movements: Increasing angle of joint (ex. Straightening arm) Moving around longitudinal axis: Moving a limb away from midline of body:. Microscopic Structure and Muscle Contraction. Muscle Structure. Muscle Fascicle (Muscle bundles)
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BELLWORK • Name the following movements: • Increasing angle of joint (ex. Straightening arm) • Moving around longitudinal axis: • Moving a limb away from midline of body:
Muscle Structure • Muscle • Fascicle (Muscle bundles) • Muscle fibers (muscle cells) • Myofibrils • Myofilaments (thick and thin)
Sarcolemma • Cell membrane of skeletal muscle cells
Microscopic Structure • 1 muscle fiber = many myofibrils • 1 myofibril = many thick and thin filaments • The thick and thin filaments form the smallest functional unit of muscle the sarcomere
Thick and Thin Filaments • Made of proteins • Structural: make up the structural framework of muscles • Contractile: involved in the process of contraction • Regulatory: not part of contraction, but they regulate it
Myosin & Actin • Actin (thin filament) has binding sites for myosin
Sliding Filament Theory • 1950s – scientists observed that the length of thick and thin filaments stayed the same during muscle contraction • This led to the Sliding Filament Theory: • During muscle contraction, the thick and thin filaments do not shorten, but slide on one another which results in the shortening of the sarcomere and the entire muscle
Sliding Filament Theory • 1. Myosin head binds to ATP • 2. Myosin head gets energized
Sliding Filament Theory • 3. Crossbridge forms between myosin head and actin
Sliding Filament Theory • 4. Power stroke causes filaments to slide
Sliding Filament Theory • 5. Another ATP molecule binds to myosin head causing it to release from actin and return to original position
Sliding Filament Theory • http://www.youtube.com/watch?v=Ct8AbZn_A8A
Sliding Filament Theory • How is the sliding filament theory similar to these doors?
Regulation • Troponin and Tropomyosin (regulatory proteins) depend on Calcium ions • Troponin: has binding site for calcium ions • Tropomyosin: covers binding site on actin
Calcium ions • What would happen if there are no Calcium ions present?
6 most important chemicals (molecules): • Myosin, actin, tropomyosin, troponin, ATP, Calcium
Exit Ticket • Kahoot.it