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Mechanics of the Unusual Basilar Membrane in Gerbil

Mechanics of the Unusual Basilar Membrane in Gerbil. Santosh Kapuria, IIT Delhi Charles Steele, Stanford Sunil Puria, Stanford. Microstructure of BM. Detailed anatomy Guinea pig: S Iurato (1962) Cat: LM Cabazudo (1978) Gerbil: Schweitzer L, Lutz C, Hobbs M, Weaver SP (1996).

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Mechanics of the Unusual Basilar Membrane in Gerbil

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  1. Mechanics of the Unusual Basilar Membrane in Gerbil • Santosh Kapuria, IIT Delhi • Charles Steele, Stanford • Sunil Puria, Stanford

  2. Microstructure of BM • Detailed anatomy • Guinea pig: S Iurato (1962) • Cat: LM Cabazudo (1978) • Gerbil: Schweitzer L, Lutz C, Hobbs M, Weaver SP (1996) Point load measurements Human: Békésy (1960) Guinea pig: Gummer WA, Johnstone BM, Armstrong NJ (1981) Miller, C (1985) Gerbil: Olson EE, Mountain DC (1994) Naidu, RC, Mountain DC (1998) Emadi G, Richter CP, Dallos P (2004)

  3. Iurato 1962,gp

  4. I- Beam

  5. Beam with constraints

  6. Gerbil organ of Corti Edge, et al. (1998) Arc of BM

  7. Gerbil OC (Corrales, 2006) 7

  8. Beam model for BM

  9. Arch model

  10. Buckling of arch

  11. Olson and Mountain 1994

  12. Emadi et al. 2004

  13. Emadi, et al. (2004)

  14. Point load on arch

  15. Pressure loading without Pillar stiffness

  16. Frequency map

  17. Fast4 model of OC

  18. Gerbil 2.75 mm, 1 kHz, wavelength = 10 mm

  19. Gerbil 2.75, with pressure amplitudes

  20. Gerbil at 2.75 mm, add axial flow amplitudes

  21. Gerbil at 2.75 mm, add axial flow amplitudes with viscosity

  22. Gerbil at BF, add axial viscosity

  23. Acknowledgement • Fulbright Fellowship to SK • NIH RO1 DC007910

  24. Close up, showing cilia and tip links

  25. IHC tip of cilium Lubrication theory TM gapTM pressL1 HS qTM Fluid displacement FD qHS Edge, et al. (1998) gapHS pressIS FD gapHS gapTM pressL1– pressIS qHS qTM d/dt = – perm * 07/07/2011

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