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2009 Health Care Forecast Conference Mike Mussallem Chairman and CEO, Edwards Lifesciences Chairman of the Board, AdvaM

2009 Health Care Forecast Conference Mike Mussallem Chairman and CEO, Edwards Lifesciences Chairman of the Board, AdvaMed. Edwards Lifesciences. Founded by Miles “Lowell” Edwards in 1958 Inventor and visionary, held 60+ patents

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2009 Health Care Forecast Conference Mike Mussallem Chairman and CEO, Edwards Lifesciences Chairman of the Board, AdvaM

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  1. 2009 Health Care Forecast Conference Mike Mussallem Chairman and CEO, Edwards Lifesciences Chairman of the Board, AdvaMed

  2. Edwards Lifesciences • Founded by Miles “Lowell” Edwards in 1958 • Inventor and visionary, held 60+ patents • Partnered with physicians to introduce breakthrough medical devices to the world • Albert Starr, Jeremy Swan, William Ganz, Thomas Fogarty, Alain Carpentier, Delos Cosgrove, Alain Cribier • Lineage • 1958 Edwards Laboratories • 1968 American Hospital Supply Corp. • 1984 Baxter International Inc. • 2000 Edwards Lifesciences (NYSE:EW)

  3. Edwards’ Businesses Cardiac Surgery Systems Minimally-Invasive Instruments Cannulae Embolic Protection Vascular Clot Management SystemsSurgical Accessories 5% 8% Critical Care Hemodynamic Monitoring Sepsis Management Access Products 36% Sales by Business 47% Heart Valve Therapy Surgical Replacement & Repair Transcatheter Replacement

  4. Advanced Medical Technology Association (AdvaMed) • World’s largest medical technology association • 1,600+ member companies and subsidiaries • Members produce 90% of sales in domestic market, 50% of sales in global market • 70%+ of member companies have <200 employees

  5. Medical Device Industry – Different Than Other Health Sectors • Companies rely on physician experience, feedback to develop better treatments • Device effectiveness depends on physician skill - product training is critical • Physician contribution/feedback plays a vital role in continued innovation • Collaboration benefits patients

  6. Industry Challenges

  7. Global economic climate

  8. Reimbursement

  9. Patient and patent lawsuits

  10. New leadership – Congress, HHS, FDA, etc.

  11. Comparative effectiveness research

  12. Greater transparency of clinician / industry relationships

  13. It’s the Patient

  14. Helping Patients is Our Life’s Work, and

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