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EXPERIENCE WITH THE USE OF Acidosalus® - A FERMENTED LACTIC PROBIOTIC WITH Lactobacillus acidophilus

EXPERIENCE WITH THE USE OF Acidosalus® - A FERMENTED LACTIC PROBIOTIC WITH Lactobacillus acidophilus. M. Brlečić 1 , I. Kosalec 2 , N. Vidić 1 , S. Večerina-Volić 3 , V. Škerk 4 1 "Nature cures", Vlaška 40, Zagreb 2, Pharmaceutical-Biochemical Faculty, Schrottova 39, Zagreb

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EXPERIENCE WITH THE USE OF Acidosalus® - A FERMENTED LACTIC PROBIOTIC WITH Lactobacillus acidophilus

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  1. EXPERIENCE WITH THE USE OF Acidosalus® - A FERMENTED LACTIC PROBIOTIC WITH Lactobacillus acidophilus M. Brlečić1, I. Kosalec2, N. Vidić1, S. Večerina-Volić3, V. Škerk4 1 "Nature cures", Vlaška 40, Zagreb 2, Pharmaceutical-Biochemical Faculty, Schrottova 39, Zagreb 3 Phoniatrics centre Šalata at the ORL Clinic Šalata, Šalata 2, Zagreb 4 Clinic for infectious diseases ‘Dr. Fran Mihaljević’, Mirogojska 8, Zagreb

  2. Lactobacillus and balance of microbes • As early as 1960, acidophilus milk and its effects were clinically tested at sections of ORL, urology, internal medicine and pediatrics in hospitals in Zagreb • For this research we are obliged to Prof. Dr. Kruna Tomić Karović • Positive experiences and scientific contribution of that research provided motivation for our project Acidosalus®

  3. Lactobacillus and balance of microbes • Lactobacillus is a constituent part of the commesal flora of the dynamic gastrointestinal system and the vagina • Colonization immediately after birth (through milk) • Balance  essence of homeostasis Fedorak et al., Curr Opin Gastro 20(2004) Acidosalus®

  4. Bacteria Lactobacillus sp. • Gram-positive bacteria of the Lactobacillaceae family, which includes around 120 species • Commesal flora, but used also as a probiotic • Lactobacillus lactis, L. plantarum, L. rhamnosus, L. bulgaricus, L. helveticus • L. acidophilus complex dominant bacteria (L. acidophilus, L. crispatus) Acidosalus®

  5. Probiotics are: • Live microorganisms which, when used in the sufficient amount, have positive healing effect on the host • Probioticschange the composition and metabolic activity of the microflora or affect the immune system, which has positive effect on the host’s health FAO/WHO: www.fao.org/es/ESN/Probio/probio.htm Macfarlane et al., Curr Opin Infect Dis, 15 (2002). Acidosalus®

  6. Acidosalus® • Protective in situ effect of Lactobacillus is described through a series of mechanisms: • Competition with pathogenic bacteria for receptors • Coaggregationimpossible adherency of pathogens • Creation of antimicrobial substances: lactic and acetic acid (pH), H2O2, diacetyl and bacteriocin: lactacyd, acidophilucin, acidocin, acidophilin Boris et al., Infect Immun 66 (1998)

  7. Favourable therapeutic effect of Lactobacillus: • Therapeutic effect presupposes peroral use of live or lyophilized bacteria aiming at colonization of the gastrointestinal system (oral cavity, duodenum, small and large intestine) or throat and oral cavity • Intravaginal instillation –local application of live or lyophilized bacteria aiming at colonization of the vaginal epithelium Acidosalus®

  8. Studies on beneficial effects of Lactobacillus treatment • Vulvovaginitis caused by candidas or bacteria Van Kesell et al., Obstet Gynecol Survey, 2003 Jeavons JOGNN, 2003 Acidosalus®

  9. Studies on beneficial effects of Lactobacillus treatment • Infections of the gastrointestinal system: Helicobacter pylori (ulcer) Clostridium difficile (pseudomembranuous colitis) Enteropathogenic bacteria (diarrhea) Candida albicans Rotaviruses Infestation with the parasite Giardia lamblia • Changes in microbial flora after antibiotic treatment, diarrhea and non-infectious diseases (Morbus Crohn, and oth.) Madden et al., Inter Immunopharmacol 2005

  10. Lactic preparation with minimally 1011/mL live Lactobacillus acidophilus Acidosalus®

  11. Experiences with use of Acidosalus®: • 80 patients with infectious and non-infectious diseases: urogenital (60%) gastrointestinal (20%): upper respiratory sytem and oral cavity (20%)

  12. Acidosalus® Application of Acidosalus® : • Depending on the type and localization of the disease: • Peroral (regime): • Vaginal instillation

  13. Application of Acidosalus® : • Why are laryngology and phoniatrics chosen? • Interconnections of pathology of the gastrointestinal vs. • respiratory system • GERD and GLRD as obvious examples of effects of the reflux mechanism from the gastrointestinal to the respiratory • (phonatory) system • Occurence of certain pathological conditions which cannot be eradicated neither by conventional nor surgical therapy • GERD and GLRD • Papillomatosis (HPV) of the larynx, hypopharinx, pharinx, • oral cavity • Fungal infections in these areas Possibility of objective digital documentation

  14. Monitoring of patients in laryngologyand phoniatrics: 1.Subjective changes 2.Objective: digital endoscopic images and video clips

  15. Monitoring of patients: • Subjective changes (a questionnaire, but non-specific) • Objective changes GERD (gastroesophageal reflux disease) GLRD (gastrolaryngeal reflux disease) GLRD or GLRD and HD

  16. Possible consequences of GERD or GLRD

  17. Back granulomas

  18. OBJECTIVE TESTS ( digital endoscopic images) Various degrees of back laryngitis

  19. OBJECTIVE TESTSdigital endoscopic images before and after therapy(8 out of 10 patients) Before ARth and AS After ARth and AS Only AR th. Pri After AS Before AS Only AR th

  20. OBJECTIVE TESTSAcidosalus only Before Acidosalus After Acidosalus

  21. OBJECTIVE TESTS Colonization of fungi at the base of the tongue Digital endoscopic image before AS (resistance to antimycotic) Digital endoscopic image after AS

  22. OBJECTIVE TESTS Human papillomavirus of the larynx and hypopharinx BEFORE AC Before th with CO2 Laser AFTER AC After th with CO2 Laser and AS

  23. Widening of use • Incorporation of Acidosalus® into bases: • Application in dermatology Application in dermatology

  24. Widening of research and use • Further research • Virosalus R in the base of goat milk with addition of garlic • Pekisalus in the base of fresh beetroot juice with addition of garlic

  25. Recommendations Conclusions • Based on the testings of 80 patients, it can be concludedthat use of thelactic probiotic preparationAcidosalus®with bacteriaLactobacillus acidophilus significantly improved the patients’ health condition at the level of subjective positive changes and with no side effects

  26. CONCLUSIONS • Using techniques of objective test evaluation for parts of the respiratory, gastrointestinal and phonatory systems, • it is possible with great accuracy to monitor effects after the therapeutic treatment • These are techniques of digital visualization in both static and dynamic form, including slow motion, and these are executed at the Phoniatrics Centre of the ORL CLINIC Šalata, the Reference Centre of the Croatian Health Ministry • The authors of this research gave such methodology priority over the questionnaire in this review Acidosalus®

  27. CONCLUSIONS Although the number of subjects should be increased, the presented objective clinical documentation shows the effects of Acidosalus®in cases of complex clinical conditions which result from disturbed local or overall immunity of the organism, i.e. biological balance. PROBIOTICS ARE PRECISELY THAT WHICH RESTORES THE BALANCE Acidosalus®

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