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Immune Mechanisms

Immune Mechanisms. Chapter 29. Immune Cells. B and T Cells. Innate Response: Phagocytosis of Bacillus megaterium. Toll Like Receptors: PAMP and PRR. Oxygen Dependent Killing in the Phagolysosome. Inhibiting Phagocytosis.

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Immune Mechanisms

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  1. Immune Mechanisms Chapter 29

  2. Immune Cells B and T Cells

  3. Innate Response: Phagocytosis of Bacillus megaterium

  4. Toll Like Receptors: PAMP and PRR

  5. Oxygen Dependent Killing in the Phagolysosome

  6. Inhibiting Phagocytosis Staphylococcus aureuscarotenoids, Mycobacterium tuberculosis cell wall glycolipids :: absorb ROS. Staphylococcus aureus, Streptococcus pyogenes :: leucocidins – toxins that kill phagocytes  pus. pyogenic = pus forming pathogens. Streptococcus pneumoniae capsules, S. pyogenesM protein – inhibit phagocytosis. Antibodies specific to capsules, M protein…overcome this escape mechanism…Ab dependent phagocytosis.

  7. Adaptive Immune Response Clicker Question:

  8. Adaptive Immune Response Clicker Question:

  9. Adaptive Immune Response Clicker Question:

  10. Three Immune Characteristicsapplies to bothAntibody Response and Cellular Response

  11. Immunogens Proteins > Polysaccharides >>>>> DNA >>>lipids

  12. Antigen Binding Clicker Question:

  13. Tcell Receptor and MHC and Ag Presentation MHC-I MHC-II T-cell Receptor

  14. Tcell Receptor Binds Ag Presented by MHC TC cell = Cytotoxic T-cell TH cell = Helper T-cell.

  15. TC Cells Killing

  16. NK Cells

  17. TH1 Cells Helpers

  18. TH2 Cells Helpers TH17 cells, secrete IL-17 and other cytokines to attrach Neutrophils to sites of infection… ….independent of Ag contact (activated by dendritic cells)

  19. Antibodies

  20. IgG Disulfide bonds circled in Red

  21. Antibodies

  22. IgG vs IgM

  23. IgM (in blood) Clicker Question:

  24. IgA: Excreted to Mucosal Surfaces Clicker Question:

  25. Ig Light Chain Molecular Biology

  26. Hey, we had this slide Last Class Clicker Question:

  27. Complement Holes in Salmonella enterica

  28. Complement is So Cool !

  29. Complement is So Cool !

  30. 3 Pathways of Complement Activation

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