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Red blood cells destruction

Red blood cells destruction. Prof: lammers Week 1 Hematology & Immunology Module. 4MedStudents.com. What happens when RBCs are destroyed?. When RBC age, they are engulfed by macrophages. RBC destructed to several products 1- Fe in the form of transferin and ferritin .

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Red blood cells destruction

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  1. Red blood cells destruction Prof: lammers Week 1 Hematology & Immunology Module 4MedStudents.com

  2. What happens when RBCs are destroyed? • When RBC age, they are engulfed by macrophages. • RBC destructed to several products 1- Fe in the form of transferin and ferritin. 2-Globulin that is broken down to simple amino acids and are reused 3- Heam that is converted to billiverdin

  3. Consequences of heam destruction abnormality • Jaundice is the main presentation of abnormalities in heam destruction • When billirubin is high >>> Jaundice • If unconjugated billirubin is high • Hemolytic anemia >>> increase RBC destruction. • If conjugated billirubin is high • Obstructive bile duct • Liver disease

  4. Reaction of the body to bleeding 1- Vasoconstriction of the veins of the least essential organs. Such as GIT, Kidney, skin (from least essential) and the most essential organ is the brain. 2- Fluid shift: flow of fluids from the extracellular space to the blood by increasing blood return to capillaries in comparison to blood loss to tissue

  5. 20 30 Hydrostatic pressure 25 25 oncotic pressure Tissue Normal fluid shift Arterial end venous end NFR= -5 NFR= +5 Hydrostatic pressure oncotic pressure

  6. Fluid shift in bleeding Arterial end venous end 10 20* Hydrostatic pressure Hydrostatic pressure 25 25 oncotic pressure oncotic pressure Tissue * The hydrostatic pressure decreases because of decrease in blood volume due to bleeding

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