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Pharmacology summary notes

Pharmacology summary notes. Cardio-Vascular Module. 4MedStudents.com. Class I Na channel blocker Class Ia: Quinidine Class Ib: Lidocaine Class Ic: Fluconide. Class II β-Blocker (-olol) Propanolol* Pindalol* Nadalol* Metoprolol** Atenolol** Acebutolol** * Non selective

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Pharmacology summary notes

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  1. Pharmacology summary notes Cardio-Vascular Module 4MedStudents.com

  2. Class I Na channel blocker Class Ia: Quinidine Class Ib: Lidocaine Class Ic: Fluconide Class II β-Blocker (-olol) Propanolol* Pindalol* Nadalol* Metoprolol** Atenolol** Acebutolol** * Non selective ** cardio-selective Class III K channel Blocker Amiodarone Sotaolol Defitilide Class IV Ca channel Blocker Verapamil Deltaiazim Nifedipine Class V Vagus Booster Digoxon Adenosine Anti-Arrhythmic Drugs

  3. Platelet Aggregation Inhibitors Non selective Cycloxygenase (COX) Inhibitors Aspirin Adenosine reuptake inhibitors Dipyradimole ADP inhibitor Clopidegrel Such as aspirin, but used when patients can’t tolerate aspirin side effects (peptic ulcer) GP IIb-IIIa inhibitors Tirofiban (non peptide) Abciximib Epitibutide

  4. Thrombolytics Streptokinase Non-selective High antigenicity Long acting Less expensive Altoplase (t-PA) Selective Low antigenicity Short acting More expensive

  5. Treatment of Angina • Nitrates: veins-dilatorsdecrease preload decrease O2 demand • β-Blocker: Decreases the HR and therefore the workload of the heart • Ca channel Blocker • -dipine: arteries-dilators decrease after load • Verapamil decrease HR and O2 demand

  6. Anti-Hypertensive Drugs • Diuretics: that decreases the preload and after load • β-Blocker(-olol) that decreases the heart rate • α2 agonist (-nidine) that decreases the sympathetic activity. It is best used with Diuretics. • Ca channel Blocker (-dipine) are arterial dilators that decreases the after load . It is best used with beta blocker • Direct acting vasodilators (Minoxidil, and Hydralazine)

  7. Anti- hypertensive drugs • ACE Inhibitors (-pril): that inhibits the conversion of angiotensin I to angiotensin II therefore causes vasodilatation, and increase Na excretion. Angiotension Receptor II Blocker (-sartan): has the same action of ACE- I and are used when patients cant tolerate the side effects of ACE-I (cough) • α1 antagonist (-zisone) arterial and venous dilator, therefore decrease preload and after load and causes reflex tachycardia, therefore it is best used with Beta blocker

  8. Drugs used in heart failure • Acute (i.v) • β1 agonist • Doputamine • Dopamine • Isoprinalline • PDE-III inhibitors • (-rinone) • Glucagone • Chronic • Digitalis • Diuretics • ACE-Inhibitors • Beta blocker

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