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Kumar et al, Chest 2009; 136:1237–1248

inappropriate. appropriate. n. p value. 597. <.0001. S. aureus. 284. .0101. S. pneumoniae. 181. <.0001. Enterococcus sp. 268. .0005. other Strep sp. 869. <.0001. E. coli. 312. <.0001. Klebsiella sp. 148. .0002. Enterobacter sp. 295. <.0001. Ps. aeruginosa. 290. <.0001.

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Kumar et al, Chest 2009; 136:1237–1248

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  1. inappropriate appropriate n p value 597 <.0001 S.aureus 284 .0101 S. pneumoniae 181 <.0001 Enterococcus sp 268 .0005 other Strep sp 869 <.0001 E. coli 312 <.0001 Klebsiella sp 148 .0002 Enterobacter sp 295 <.0001 Ps. aeruginosa 290 <.0001 C. albicans 153 .0002 non-albicans yeast 0.1 1 10 100 0 20 40 60 survival (%) odds ratio Kumar et al, Chest 2009; 136:1237–1248

  2. Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest 2009; 136:1237–1248

  3. Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock n p value <.0001 5715 <.0001 4056 <.0001 1659 <.0001 2013 <.0001 2044 <.0001 2144 <.0001 1912 <.0001 1381 <.0001 1041 <.0001 344 <.0001 499 <.0001 205 <.0001 236 1 10 100 1000 Odds Ratio Kumar et al, Chest 2009; 136:1237–1248

  4. inappropriate appropriate n p value 5715 <.0001 all 4056 <.0001 culture+ 1659 <.0001 culture - 2013 <.0001 bacteremia + 2044 <.0001 bacteremia - 2144 <.0001 community 1912 <.0001 nosocomial 1 10 100 0 20 40 60 survival (%) odds ratio Kumar et al, Chest 2009; 136:1237–1248

  5. Kumar et al, Chest 2009; 136:1237–1248 inappropriate appropriate n p value 1381 <.0001 pneu 1041 <.0001 IAI 344 <.0001 sst 499 <.0001 uti 205 <.0001 cri 236 <.0001 pbi 1 10 100 0 20 40 60 80 survival (%) odds ratio

  6. inappropriate appropriate n p value 597 <.0001 S. aureus 284 .0101 S. pneumoniae 181 <.0001 Enterococcus sp 268 .0005 other Strep sp 869 <.0001 E. coli 312 <.0001 Klebsiella sp 148 .0002 Enterobacter sp 295 <.0001 Ps. aeruginosa 290 <.0001 C. albicans 153 .0002 non-albicans yeast 0.1 1 10 100 0 20 40 60 survival (%) odds ratio Kumar et al, Chest 2009; 136:1237–1248

  7. inappropriate appropriate p value n 1355 <.0001 g+c 2002 <.0001 g-b 156 .0048 anaerobes 443 <.0001 yeast 1 10 100 0 20 40 60 survival (%) odds ratio Kumar et al, Chest 2009; 136:1237–1248

  8. Kumar et al, Chest 2009; 136:1237–1248

  9. Kumar et al, Chest 2009; 136:1237–1248

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