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Report. Wen Hao Chen. Part I. High efficient self-assembled silano-films and their protecting group effects. Outline. Part I: High efficienct self-assembled silano -films and their protecting group effects Total synthesis of MPS Contact angle X-ray photoelectron spectroscopy

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Report

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  1. Report WenHao Chen

  2. Part I High efficient self-assembled silano-films and their protecting group effects

  3. Outline Part I: High efficienct self-assembled silano-films and their protecting group effects • Total synthesis of MPS • Contact angle • X-ray photoelectron spectroscopy • SEM for using MPS immobilization AuNP • UV-vis Absorption V.S. AuNP coverage on glass surface • Immobilization kinetic curve of self-assembled silano-films • pHs of different MPS • Solvent effect (organic phase) • Ac-MPS modified substrate surface in aqueous • Real time AuNP binding curve (Ac-MPS) • Refractive index sensitivity of Nc-MPS modified AuNP • AFM • Degradation of SAMs on glass • Refractive index sensitivity of Ac-MPS modified AuNP • Bio-test of Ac-MPS (goat anti-rabbit binding rabbit antibody)

  4. Anti-nonspecific adsorption self-assembled monolayer

  5. Outline Part II : Development SAM that resist Nonspecific Adsorption • Total synthesis of zwitterionicself-assembled molecular • Stabilization test • Different time of immobilization anti non-specific adsorption molecular • Solvent effect (Hoffman Elimination) • Anion effect • Anti non-specific adsorption (Serum) • Real time bio-test

  6. AgOH

  7. Modification time (hr)

  8. Log (g/ml) Log (g/ml)

  9. Thank you for your attention

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