1 / 26

Exploring Ceramide Signaling Pathways for Cellular Homeostasis

Discover the multifaceted role of ceramide in cellular signaling pathways, impacting growth, apoptosis, and differentiation. Uncover the biophysical properties and metabolic enzymes involved in ceramide synthesis and metabolism. Learn about sphingolipid metabolites and their crucial functions in cell fate regulation.

eluke
Download Presentation

Exploring Ceramide Signaling Pathways for Cellular Homeostasis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Hannun and Luberto, 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10:73-79 Huwlier, et al., 2000.Physiology and pathophysiology of sphingolipid metabolism and signaling. BBA 1485:63-99. Kolesnick, er al., 2000. Comaprtmentalization of ceramide signaling: physical foundations and biological effects. J. Cell Physiol. 184:285. Perry & Hannun, 1998. The role of ceramide in cell signaling . BBA 1436:233. Pyne, S, & Pyne, N. 2000. Sphingosine 1-phosphate signaling in mammalian cells. Biochem. J. 349:385-402. Spiegel & Milstein, 2000. Sphingolipid metabolites in signal transduction. From Signaling networks and cell cycle control, Ed. S. Gutkind, Humana Press, NJ, pp379-391. Spiegel & Milstein. 2000. Sphingosine-1-Phosphate: signaling inside and out FEBS lett. 476:55-57. Oliviera & Spiegel, 2001. Sphingosine kinase: a mediator of vital cellular functions. Prostaglandins Lipid Med. 64:123-134. Venkataraman, K., and Futerman, A.H. 2000. Ceramide as a second messenger:sticky solutions to sticky problems. Trends Cell Biol. 10:408-412,

  2. Sphingolipid Signaling • Role of Ceramide and Sphingosine in Cell death • Role of Spingosine-1-phosphate in cell survival

  3. Four main types of phospholipids in plasmamembranes

  4. Ceramide has a Sphingosine backbone

  5. Biophysiclal Properties of Ceramide Ceramide, red Sphingolipids, blue Cholesterol, green Ceramide forms natural microdomains: CRD (ceramide rich domains) Venkataraman & Futerman, 2000. Trends Cell Biol. 10:409.

  6. (a) direct, (b) via ceramide transfer proteins, (c,d) receptor-activation Venkataraman & Futerman, 2000. Trends Cell Biol. 10:411.

  7. Enzymes in Ceramide Metabolism • Sphingomyelinase (A and N) • Sphingomyelin Synthase • Ceramide Kinase • Ceramidase • Glycosyl Ceramide Synthase • Ceramide Synthase

  8. Perry & Hannun, 1998. BBA 1436:234

  9. Huwlier, et al.,2000. BBA 1485:71.

  10. Sphingolipid Metabolism Pyne & Pyne, 2000. Biochem J. 349:386.

  11. Huwlier, et al.,2000. BBA 1485:72.

  12. De novo Ceramide Synthesis Pyne & Pyne, 2000. Biochem J. 349:386.

  13. Ceramide Effects 1. Growth arrest 2.Apoptosis 3.Proliferation 4. Differentiation Perry & Hannun, 1998. BBA 1436:235

  14. Ceramide effectors 1. CAPP: ceramide activated protein phosphatase (PP2A) 2 PP1: protein phosphatase 1 3. CAP kinase: ceramide-activated protein kinase 4.Protein kinase C x 5. C-Raf1

  15. Ceramide Siganling in Apoptosis

  16. Ceramide activation by TNFa Hannun and Luberto, 2000. Trends Cell Biol. 10:77

  17. Sphingolipids in Multidrug Resistance Siestma, et al., 2001. J. Memb. Biol. 181:153

  18. Ceramide Metabolism Hannun & Luberto, 2000 trends Cell Biol. 10:78.

  19. Sphingosine-1-PO4 Signaling

  20. S1P mediated signal cascades

  21. Possible Intracellular Actions of S1P Pyne & Pyne, 2000. Biochem.J. 349:394

  22. Model for Signal termination at EDGRs Pyne & Pyne, 2000. Biochem.J. 349:385-402.

  23. Regulation of Cell Fate by Sphingolipids Pyne & Pyne, 2000. Biochem.J. 349:396

More Related