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Prof. Dr. Christian Burri Head of Department

Department of Medicines Research. London, 6 th May 2014 Malaria - o n the road to malaria elimination? All-Party Parliamentary Group on Malaria & Neglected Tropical Diseases. Prof. Dr. Christian Burri Head of Department. Swiss Tropical & Public Health Institute. The Swiss TPH …

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Prof. Dr. Christian Burri Head of Department

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  1. Department of Medicines Research London, 6th May 2014 Malaria - on the road to malaria elimination? All-Party Parliamentary Group on Malaria & Neglected Tropical Diseases Prof. Dr. Christian Burri Head of Department

  2. Swiss Tropical & Public Health Institute The Swiss TPH … • … the Swiss Tropical Institute (STI) was founded in 1943 as a public organisation based on a local government act • … is an associated institute of the University of Basel • … has the mandate to contribute to the improvement of the health of populations internationally and nationally through • excellence in research, services, and teaching & training at the levels of • innovation, validation & application • … has over 650 staff from over 60 nations, thereof ~80 PhD students

  3. IntroductionMalaria cases and deaths in DRC Source: WHO World Malaria Report 2013

  4. MATIAS studyGoal • “(Severe) Malaria Treatment with Injectable Artesunate” • Despite change of WHO guidelines quinine still treatment of choice for treatment of severe malaria in DRC • To inform the NMCP of the DRC about the operational requirements and challenges of nationwide rolled out of injectable artesunate through a limited scope implementation study

  5. MATIASStudy design • Descriptive implementation study with a before-after evaluation in confirmed severe malaria cases • Investigate operational issues • Basic clinical assessment • Time & motion study • Feasibility & acceptability • Nov 12 Jan 13 Apr 13 June 13 Quinine Injectable artesunate N=399 N=350

  6. Study sites HZ of Maluku 2 study sites - CS HZ of Masina 1 study site - Hospital HZ of Kimpese 3 study sites - Hospital + 2 CS Dem Rep Congo  HZ of Kisantu 2 study sites - Hospital + 1 CS

  7. MATIAS studyStakeholders involved in process

  8. ResultsKey outcomes

  9. MATIASDissemination • Inclusion into strategic plan 2013 – 2015 of NMCP • Progressive implementation within 3 years (30, 50, 100%) • Projected need for DRC

  10. CHB Malaria eliminationAccess & sustainable success SANRU Program SANRU Program CHB

  11. http://www.swisstph.ch

  12. MATIASHaemoglobin trend at follow up visits (Artesunate) • Serious adverse events during follow up • 7 SAEs reported in relation to anemia (2.0%) • 2 patients referred to hospital • 3 patients required blood transfusion • 1 persistent form • No fatality

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