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Supplemental Fig. S1. A. Wild Type. RanBP9 Tg. CA1. TUNEL. The scale bar represents 50 m m. B. P<0.0005. 200. *. Condensed TUNEL + cells (%). 100. 0. WT. RanBP9 Tg. Supplemental Fig. S2. B. A. D. C. Supplemental Fig. S3. Supplemental Fig. S4. Supplemental Fig. S5. A. VC.

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  1. Supplemental Fig. S1 A Wild Type RanBP9 Tg CA1 TUNEL The scale bar represents 50mm B P<0.0005 200 * Condensed TUNEL + cells (%) 100 0 WT RanBP9 Tg

  2. Supplemental Fig. S2 B A D C

  3. Supplemental Fig. S3

  4. Supplemental Fig. S4

  5. Supplemental Fig. S5 A VC RanBP9 C UL: 2.42 UR: 28.40 LL: 47.36 LR: 21.82 UL: 0.68 UR: 24.56 LL: 29.62 LR: 45.14 250 PI O F 150 21.87% 45.14% Stacking gel 100 D 75 Annexin V Annexin V B O.D at 490/690 nm fibril VC RanBP9 50 37 25 Thy1.2 RanBP9 20 GFP- RanBP9 VC 15 pEYFP-N1 10 tetramer trimer dimer pEYFP-N1 GFP RanBP9 monomer 4 6E10

  6. DAPT 5μM Supplemental Fig. S6 DAPT 5μM Cont. RanBP9 siRNA siRNA Control Control * RanBP9 * β-actin APP-FL APP-CTFs C A B Cont. Cofilin siRNA siRNA • * Cofilin • * β-actin HT22 Cells

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