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Efector functions of CD4 + and CD8 + T-cells

Efector functions of CD4 + and CD8 + T-cells. Th1. Naivna CD4 + T. Naiv e CD4 + T. Th17. Th2. Defense- intracellular pathogens, stimulation of IgG production. Or gan-specific autoim m une diseases. Defense- helmints. Allergy. Defense- e x tracel l ular bacteria, fungi.

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Efector functions of CD4 + and CD8 + T-cells

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  1. Efector functions of CD4+ and CD8+ T-cells

  2. Th1 Naivna CD4+T Naive CD4+T Th17 Th2 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation

  3. Th1 Naivna CD4+T Naive CD4+T Th17 Th2 Macrofage activation B-cells IFN-γ IL-12 T-bet IL-4 IL-5 IL-13 Eosinophil activation B-cells… IL-4 GATA-3 IL-17 IL-22 Neutrophil activation... IL-23 RORgt

  4. TH1 response

  5. Efector functions of TH1 cells • Macrophage activation at the site of infection

  6. Efector functions of TH1 cells • Macrophage activation at the site of infection

  7. Efector functions of TH1 cells • Macrophage activation at the site of infection

  8. Efector functions of TH1 cells • Macrophage activation at the site of infection

  9. Efector functions of TH1 cells • Macrophage activation at the site of infection

  10. Efector functions of TH1 cells • Macrophage activation at the site of infection

  11. Efector functions of TH1 cells • B-cell activation

  12. Th1 Naivna CD4+T Naive CD4+T Th17 Th2 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation

  13. TH2 response

  14. Th1 Naivna CD4+T Naive CD4+T Th17 Th2 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation

  15. TH17 response

  16. Th1 Naivna CD4+T Naive CD4+T Th17 Th2 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation

  17. CTL effector function

  18. Mechanisms of CD8+ T-cell cytotoxicity

  19. Mechanisms of CD8+ T-cell cytotoxicity

  20. Mechanisms of CD8+ T-cell cytotoxicity

  21. Mechanisms of CD8+ T-cell cytotoxicity

  22. Mechanisms of CD8+ T-cell cytotoxicity Target cell CD8+ CTL

  23. Mechanisms of CD8+ T-cell cytotoxicity perforin Target cell CD8+ CTL

  24. Mechanisms of CD8+ T-cell cytotoxicity perforin granzimi Target cell CD8+ CTL apoptosis

  25. Mechanisms of CD8+ T-cell cytotoxicity Target cell CD8+ CTL FasL

  26. Mechanisms of CD8+ T-cell cytotoxicity Ciljna ćelija CD8+ CTL apoptosis FasL Fas

  27. Pathogens avoid cellular immunity Inhibition of fusion of phagosome with lysosome

  28. Inhibition of presentation of viral antigens 0

  29. Inhibition of immune response by virokines and viroreceptors

  30. 1. Subpopulations of efektor CD4+ T-cellsare a. production of IL-4, IL-5, IL-13 Inflammatory reaction rich in eosinophils b. 2. TH1 effector function is 3. TH1 cells are important for defense against c. helminats 4. TH2effector function is d. TH1, TH2 i TH17 e. alternativemacrophage activation 5. TH2cells are important for defense against f. mobilises and activates neutrophils 6. TH2 subpopulation induces g. IFN-γ production andmacrophage activation 7. IL-4 and IL-13 inducealso h. intracellular pathogens 8. IL-17 perforin, granzymes, Fas-FasL interaction CTL effector function is i. 9. 10. CTL killing mechanisms are j. killing virus-infected and tumor cells d. g. h. a. c. b. e. f. j. i.

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