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Patrick An Introduction to Medicinal Chemistry 3/e Chapter 9 DRUG DISCOVERY: FINDING A LEAD

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 9 DRUG DISCOVERY: FINDING A LEAD Part 4: (Lead compounds - Impact of the human genome project). Contents Part 4: Lead compounds - Impact of the human genome project 4.5. Lead Compounds

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Patrick An Introduction to Medicinal Chemistry 3/e Chapter 9 DRUG DISCOVERY: FINDING A LEAD

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  1. Patrick An Introduction to Medicinal Chemistry 3/e Chapter 9 DRUG DISCOVERY: FINDING A LEAD Part 4: (Lead compounds - Impact of the human genome project)

  2. Contents Part 4: Lead compounds - Impact of the human genome project 4.5. Lead Compounds - Impact of the human genome project (6 slides) 4.6. Lead Compounds - de novo design (6 slides) 4.7. Design of Lead Compounds using NMR Spectroscopy (11 slides) [24 slides]

  3. Targets Lead compounds 4.5 Lead Compounds - Impact of the human genome project The Past Lead Compound The Future Targets

  4. 4.5 Lead Compounds - Impact of the human genome project

  5. 4.5 Lead Compounds - Impact of the human genome project

  6. 4.5 Lead Compounds - Impact of the human genome project

  7. 4.5 Lead Compounds - Impact of the human genome project

  8. 4.5 Lead Compounds - Impact of the human genome project

  9. 4.6 Lead Compounds - de novo design

  10. 4.6 Lead Compounds - de novo design X-RAY CRYSTALLOGRAPHY

  11. 4.6 Lead Compounds - de novo design PROTEIN STRUCTURE

  12. 4.6 Lead Compounds - de novo design Receptor

  13. Scaffold CH3 + O Scaffold H3N Scaffold Scaffold Scaffold HO H-BOND CO2- IONIC BOND VDW BOND

  14. HN NH N O O O S N N N O S O N O H2N 4.6 Lead Compounds - de novo design THYMIDYLATE KINASE INHIBITOR LEAD COMPOUND Optimisation ANTICANCER AGENT

  15. 4.7 Design of Lead Compounds using NMR Spectroscopy NMR SPECTROSCOPY

  16. 4.7 Design of Lead Compounds using NMR Spectroscopy Binding Site Protein

  17. 4.7 Design of Lead Compounds using NMR Spectroscopy Protein NO OBSERVABLE BIOLOGICAL EFFECT

  18. CH3 CH CH CH3 CH2 CH2 CH C C 4.7 Design of Lead Compounds using NMR Spectroscopy 13C NMR

  19. 4.7 Design of Lead Compounds using NMR Spectroscopy CH3 CH CH CH3 CH2 CH2 CH C C 13C NMR

  20. 4.7 Design of Lead Compounds using NMR Spectroscopy Protein Optimise epitope

  21. 4.7 Design of Lead Compounds using NMR Spectroscopy Protein Optimise epitope Optimise epitope

  22. 4.7 Design of Lead Compounds using NMR Spectroscopy Link Protein Optimise epitope Optimise epitope

  23. 4.7 Design of Lead Compounds using NMR Spectroscopy LEAD COMPOUND

  24. Me 4.7 Design of Lead Compounds using NMR Spectroscopy Design of a lead compound as an immunosuppressant Epitope B Epitope A

  25. Me 4.7 Design of Lead Compounds using NMR Spectroscopy Design of a lead compound as an immunosuppressant Lead compound

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