EyeCheck Pupillometery WELCOME PRESENTED TO: AngloGold Ashanti Pty Ltd

1. EyeCheck® PupillometeryWELCOMEPRESENTED TO: AngloGold Ashanti (Pty) Ltd Presented by: Imelda Neate June 17th, 2009

2. COMPANY INTRODUCTION Africa – DTA (Pty) Ltd Australia – DTA (Pty) Ltd New Zealand – DTP (Pty) Ltd Europe – EyeCheck® Europe Drug Testing Africa has been in Africa since the end of 2006. Our sister company Drug Testing Australia used to supply Africa from Australia – for logistic purposes we decided to open up a branch in South Africa. The group has been trading in the diagnostic testing industry since 1996. The company's mission is to be a preferred supplier of high quality sophisticated and innovative diagnostic assays to consumers and professionals. With that in mind, Drug Testing Africa has been in Africa since the end of 2006. Our sister company Drug Testing Australia used to supply Africa from Australia – for logistic purposes we decided to open up a branch in South Africa. The group has been trading in the diagnostic testing industry since 1996. The company's mission is to be a preferred supplier of high quality sophisticated and innovative diagnostic assays to consumers and professionals. With that in mind,

3. PRODUCTS AND SERVICES Diagnostic testing equipment In-vitro test kits (on-site) Substance of Abuse Tests Cardiac Markers Infectious Disease tests Tumour Marker Tests Devices EyeCheck® Fit for Duty programs Fatigue management Substance of Abuse Testing Equipment In-vitro test kits (on-site) Drugs of Abuse Tests Cardiac Markers Infectious Disease tests Tumour Marker Tests Testing Equipment In-vitro test kits (on-site) Drugs of Abuse Tests Cardiac Markers Infectious Disease tests Tumour Marker Tests

4. PRODUCTS AND SERVICES II Testing Service On-site testing service using qualified Testing Officers Laboratory confirmation testing Legal services Workplace policy together with Deloitte legal Training courses Testing Officer Education and awareness

5. WHAT IS PUPILLOMETERY? Imaging - relevant Scattered light – absolute The reaction or reflex of the human pupil to light and its characteristics provides invaluable information and insight to the brain sensory and motor function.

6. PUPIL PHYSIOLOGY Impairment is controlled by the Central Nervous System (CNS)

7. PUPIL REACTION Depending on the strength of the light source, the pupil contracts and dilates.

8. PUPILLOMETERY

9. THE PUPIL CARD

10. PUPIL SIZE CHANGE Is there a difference between pupil size change?

11. SELECTING A SCREENING TOOL What criteria should be taken into consideration when selecting a screening tool?

12. SELECTION CRITERIA High sensitivity and specificity Strong positive and negative predictive values Medically accepted practice Simple and practical to use Low unit cost Capacity to detect impairment

13. CURRENT AVAILABLE TESTING METHODS Measurement of signs using DRE-type protocols Saliva testing Urine testing Blood testing Observation of general signs of impairment

14. “CONS” OF CURRENT TESTING METHOFS Expense Time consuming Invasive Body Fluid exposure Tests are limited by “cut off levels” In some case impairment not detected

15. THE EyeCheck® PUPILLOMETER MCJ Inc. – The USA

16. THE EyeCheck® PUPILLOMETER II Optical instrument that measures absolute pupil dynamics by a light stimulus Hand held, weighing 1.1 kg’s Software driven from a lap top or tower Screens for human impairment Pass/Fail indicator

17. INPUT PRINCIPLE

18. INPUT PRINCIPLE II Some of the scattered light returns from the eye in an optical beam The optical power is measured over a period of time

19. INPUT PRINCIPLE III The optical power, measured over a period of time, provides the measurements relating to pupillary dynamics

20. EyeCheck® TESTING PROCEDURE EyeCheck® determines alignment of the test subject’s pupil looking at the target 30 second dark adaptation A flash of light (100 milliseconds) occurs causing the pupil to respond EyeCheck® scans and measures the response for three (3) seconds Only one scan is taken Results are instant

21. TEST PROCEDURE - OPTICAL PATTERN

22. TEST PROCEDURE – DARK ADAPTION

23. TEST PROCEDURE – DO NOT BLINK

24. TEST PROCEDURE – USER BLINK

25. TEST PROCEDURE - SCAN RESULTS

26. TEST PROCEDURE – PASS / FAIL RESULT

27. CURRENT TESTING SOFTWARE AVAILABLE Substances Alcohol and drugs including narcotics Fatigue Bio-Chemicals Diabetes Deception

28. SOFTWARE BEING DEVELOPED HIV Malaria Dengue Fever Chikungunya Fever Alzheimers

29. WORKING DEFINITION OF “DRUGS”

30. NORMAL RESPONSE CURVE

31. RESPONSE CURVE – BAC 0.10

32. RESPONSE CURVE - BENZODIAZEPINES

33. RESPONSE CURVE - MARIJUANA

34. RESPONSE CURVE – NARCOTIC ANALGESICS

35. DEFINITION OF “FATIGUE” Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment. Fatigue can be acute and come on suddenly or chronic and persist.

36. FATIGUE AND SUBSTANCES Fatigue sufferers are susceptible to increase their intake of Alcohol Drugs Medication (cross counter and prescribed) Leads to further stresses on the body, increases the fatigue levels and can also lead to substance dependence (addiction)

37. MANAGING FATIGUE IN THE WORKPLACE Management program Testing Monitoring

38. MANAGING AND MONITORING Fatigue Management program Continues monitoring Testing Adjusting

39. MEXICO SUCCESS – GRUPO TRANSPAIS Tampico – Monterrey – Tampico. (1042 km. Round Trip) Start on September 9th. Total Drivers Tested: 159. Total Kms. drived: 1,012,122

40. MEXICO SUCCESS – GRUPO TRANSPAIS II

41. MEXICO SUCCESS – GRUPO TRANSPAIS III

42. SOME OF EyeCheck® END USERS USA… Law Enforcement, Probation, Prisons, Industry Australia.. Law Enforcement, Mines, Sugar Industry Mexico.. Transportation

43. STUDIES - Illinois State Police StudyDecember 2003 – CONCLUSION

44. FURTHER STUDIES AND REPORTS Refer to handouts

45. THANK YOU www.eyecheck.co.za www.drugtesting.co.za