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BBS3027 2000: Infectious Diseases

BBS3027 2000: Infectious Diseases. Dr Garwin Sing garwinS@qimr.edu.au http://trishul.sci.gu.edu.au/courses/bbs3027/. Gut Mucosa. Gut Mucosa. Mucosal Epithelium. Epithelial Barriers to Microbial Infection: Physical. Epithelial cells joined by tight junctions Exfoliation of surface cells

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BBS3027 2000: Infectious Diseases

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  1. BBS3027 2000: Infectious Diseases Dr Garwin Sing garwinS@qimr.edu.au http://trishul.sci.gu.edu.au/courses/bbs3027/

  2. Gut Mucosa

  3. Gut Mucosa

  4. Mucosal Epithelium

  5. Epithelial Barriers to Microbial Infection: Physical • Epithelial cells joined by tight junctions • Exfoliation of surface cells • Mucous flow by ciliated epithelia (respiratory tract)

  6. Epithelial Barriers to Microbial Infection: Chemical • Enzymes: Lysozyme (tears, saliva, sweat) Pepsin (stomach) • pH: Fatty Acids/amino acids (skin) Gastric acids (stomach) • Antimicrobial: Transferrin (mucus)

  7. Epithelial Barriers to Microbial Infection: Competition • Gut Flora

  8. Protection from Infectious Agents • Innate Immunity Fever, interferon, neutrophils, macrophages, NK cells • Adaptive Immunity B cells, T cells

  9. Congenital Infections

  10. Anatomy Physiology Immunity Commensals Viruses Bacteria Fungi Parasites

  11. Sources of Infection: Exogenous • Inhalation Common cold, flu, Legionnaire’s Disease, Coccidioidomycosis • Ingestion Typhoid fever, tapeworm, cryptosporidium, Hepatitis A • STD Gonorrhea, HIV • Wound Tetanus, Rabies • Insect Bite Malaria, Yellow Fever, Dengue

  12. Sources of Infection: Endogenous • Gut e.g E coli • Skin e.g. staphylococcus • Tonsils • Throat e.g streptococcus • Blood e.g. EBV • Lungs e.g Candida, CMV, streptococcus

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