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Pol II. P. P. P. P. BARD1. BARD1. BRCA1. BRCA1. Rad51. Rad51. BRCA2/FANCD1. BRCA2/FANCD1. DNA damage. BARD1. CstF50. BARD1. BRCA1. (a). BRCA1. Pol II. P. P. P. P. Transcription, DNA damage sensor ?. BACH1. BARD1. (b). BARD1. BACH1. Intra-S checkpoint signal. BRCA1.

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  1. Pol II P P P P BARD1 BARD1 BRCA1 BRCA1 Rad51 Rad51 BRCA2/FANCD1 BRCA2/FANCD1 DNA damage BARD1 CstF50 BARD1 BRCA1 (a) BRCA1 Pol II P P P P Transcription, DNA damage sensor ? BACH1 BARD1 (b) BARD1 BACH1 Intra-S checkpoint signal BRCA1 BRCA1 P TopBP1 MSH2 TopBP1 MSH6 MLH1 DNA replication point Replication inhibition CtIP BARD1 BRCA1 BARD1 (c) Non-homologous end-joining CtIP BRCA1 P Nbs1 Rad50 Nbs1 Mre11 Rad50 Mre11 DNA-PK ATM ATRIP Chk1 ATR Chk2 (d) Homologous recombination G2/M checkpoint signal Once dispersed S-phase dot supercomplex ABRA1 phosphorylation P ABRA1 BARD1 (e) RAP80 P BRCA1 RAP80 BARD1 u u Polyubiquitin cahins u u BRCA1 BRCC36(DUB) K6 or K63-link u u u u

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