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Anion Gap

Anion Gap. represents the concentration of all the unmeasured anions in the plasma concentrations are expressed in units of milliequivalents /liter ( mEq /L) NV: 8-16 mEq /L. Major Clinical Uses of the Anion Gap . To signal the presence of a metabolic acidosis and confirm other findings

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Anion Gap

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  1. Anion Gap • represents the concentration of all the unmeasured anions in the plasma • concentrations are expressed in units of milliequivalents/liter (mEq/L) • NV: 8-16 mEq/L

  2. Major Clinical Uses of the Anion Gap • To signal the presence of a metabolic acidosis and confirm other findings • Help differentiate between causes of a metabolic acidosis: high anion gap versus normal anion gap metabolic acidosis. • To assist in assessing the biochemical severity of the acidosis and follow the response to treatment

  3. Anion Gap With potassium = ( [Na+]+[K+] ) − ( [Cl−]+[HCO3−] ) = (138 + 4.2) – (108+10) = 24.2 mEq/L - HIGH Without potassium = ( [Na+] ) − ( [Cl−]+[HCO3−] ) = (138) – (108+10) = 20.0 mEq/L - HIGH

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