Preventing the development and spread of Antimicrobial Resistance

1. Preventing the development and spread of Antimicrobial Resistance NIHR Public Health Research Programme Dr Claire Kidgell, Senior Programme Manager Dr Andrew Cook, Consultant Advisor www.themedcalls.nihr.ac.uk/amr

2. Webinar overview • Introduction to the AMR Themed Call • Introduction to the PHR Programme • Tips for success • Questions www.themedcalls.nihr.ac.uk/amr

3. What is a themed call? • NIHR themed calls are issued to meet an identified health challenge or government priority • Calls are generally issued once a year • Cross NIHR initiative involving all NIHR research programmes • Previous calls have focused on: • Dementia • Surgery • Primary Care Interventions • Very Rare Diseases

4. NIHR Antimicrobial Resistance themed call • Part of coordinated response by the NIHR to the publication of the 2nd volume of the 2011 Annual Report of the Chief Medical Officer: Infections and the rise of antimicrobial resistance. • For research into the evaluation of public health measures, health care interventions and health services to reduce the development and spread of antimicrobial resistance and consequent morbidity • Provides opportunities to evaluate interventions which cross NIHR programme boundaries and applications which span the remit of one or more NIHR programme will be considered. www.themedcalls.nihr.ac.uk/amr

5. AMR Website www.themedcalls.nihr.ac.uk/amr

6. Which NIHR programme? EME– exploratory trials, less pragmatic, phase 2-3, efficacy, mechanisms if possible HTA– systematic reviews, large multicentre pragmatic trials or other studies (phase 3-4), effectiveness in the NHS HS&DR– organisational, patient experience, qualitative or other i4i - translation of bright ideas for new high-tech products into methods of prevention, diagnosis and treatment PHR – effectiveness and cost effectiveness of non-NHS interventions to improve public health PGfAR- £2m for up to 5 years, awards made to NHS bodies RfPB – max £350k for up to 36 months. Encourages proposals for projects covering a wide range of health service issues and challenges which translate into patient benefit locally and for the wider NHS. www.themedcalls.nihr.ac.uk/amr

7. www.phr.nihr.ac.uk

8. Introduction to PHR Programme Purpose and Remit To evaluate public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of non-healthcare interventions intended to improve the health of the public and reduce inequalities in health The scope of the programme is multi-disciplinary and broad covering a range of public health interventions. www.phr.nihr.ac.uk

9. Possible Areas for Research • Better prevention • Improved surveillance, monitoring and diagnosis • More effective use of existing antibiotics • Behavioural issues that can affect antibiotic use, the development or spread of AMR • Organisation-wide initiatives in hospitals, practices and the community to improve stewardship of antibiotics • Improved education and training • Evaluations of the efficacy and mechanisms of interventions • Public health measures outside of healthcare settings to prevent the occurrence and transmission of antimicrobial resistance. www.themedcalls.nihr.ac.uk/amr/resources

10. www.themedcalls.nihr.ac.uk/amr/resources/specificationdocument/possible-researchwww.themedcalls.nihr.ac.uk/amr/resources/specificationdocument/possible-research

11. Applying to the AMR call • Applications should meet the remit of the AMR specification document and the PHR Programme • Applications received to the PHR Programme but not in remit will be transferred to other participating NIHR Programmes where appropriate • Provides opportunities to evaluate interventions which cross NIHR programme boundaries and applications which span the remit of one or more NIHR programme will be considered • Closing date for applications to the PHR Programme in response to the NIHR AMR themed call 1pm, 19 November 2013 • However, the PHR programme will continue to welcome applications in this area after the call has closed www.themedcalls.nihr.ac.uk/amr

12. Process for Assessment of Applications Screening assessment: • remit Programme Advisory Board: • public health importance Research Funding Board: • scientific quality • feasibility • value for money

13. Tips For Success

14. Keep to the remit Or carefully justify deviations

15. Give sufficient detail But not too much

16. Pick a design to minimise bias A non-randomised design is a very hard sell if a randomised design is possible.

17. Have the right team Two psychologists are not a multidisciplinary team, even if they trained at different universities.

18. Value for Money We’ll pay a lot to answer an important question – but we will consider overall value and opportunity cost

19. …and at full proposal You will get feedback on your outline proposal. Respond to every point. You may disagree with the board, but don’t ignore them.

20. NIHR Support Available http://www.themedcalls.nihr.ac.uk/amr/resources/support

21. For more information visit: www.phr.nihr.ac.uk&www.themedcalls.nihr.ac.uk/amr Enquiries welcome: info@phr.ac.uk or +44 (0)23 8059 9697 (24 hour answer phone) Closing date for applications to the PHR Programme in response to the NIHR AMR themed call 1pm, 19 November 2013 Questions?