1 / 10

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds. Sarah Canch é Lee Lab Group. Malaria, Leishmaniasis, and Trypanosomiasis. Diseases caused by protozoan parasites transmitted by mosquitoes, sand flies, and tsetse flies. Some Symptoms. Malaria:

errin
Download Presentation

Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Synthesis of Chalcones: Starting Materials for the Synthesis Of Parasite-targeted Compounds Sarah Canché Lee Lab Group

  2. Malaria, Leishmaniasis, and Trypanosomiasis • Diseases caused by protozoan parasites transmitted by mosquitoes, sand flies, and tsetse flies

  3. Some Symptoms Malaria: • Dry cough, fever, headache, fatigue, body aches Leishmaniasis: • Skin sores, fever, visceral swelling Trypanosomiasis: • Muscle and joint aches, fever, confusion, slurred speech

  4. Widespread Problem: Malaria: • 1-3 million deaths per year Trypanosomiasis: • 50,000 to 70,000 cases per year Leishmaniasis: • 10-15 million have it, with 1.5 to 2 million new cases per year • Treatment for these diseases is expensive and not always effective • Parasites can develop resistance • Need to make treatments that are more affordable and effective

  5. Pentamidine and Furamidine • Molecule currently being used to fight parasitic diseases • Destroys parasite DNA • Molecule that has been proven to help fight parasitic diseases. • Goal: Make a molecule similar to this • Increase potency • Cheaper to produce Pentamidine Furamidine

  6. Synthetic Pathways Diarylpyrazolediamidine Synthesis Thioxopyrimidine Synthesis

  7. How to synthesize chalcones: Method 1 To make… 86% yield 94% yield

  8. Method 2 65% yield 6 M NaOH MeOH Reflux 94% yield • Methanol added to flask • Reaction mixture heated to reflux • 1 M NaOH added to the mixture • Solid forms • Solid collected by vacuum filtration

  9. What I learned • Run an NMR • Run an IR • Perform TLC analysis • ChemDraw • Rotovap

  10. Acknowledgements • Dr. Moses Lee • Drs. Toni Brown & Hilary Mackay • Kristin Dittenhafer • Lee Lab Group • REACH • Hope College Chemistry Department • Conjura Pharmaceuticals, LLC

More Related