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Hydrolysis of Glucose-6-Phosphate

Hydrolysis of Glucose-6-Phosphate. ∆Gº  = –3.3 kcal/mol. = –13.8 kJ/mol. High ∆Gº  Hydrolysis Compounds. ∆Gº  = –14.8 kcal/mol = –61.9 kJ/mol. High ∆Gº  Hydrolysis Compounds. ∆Gº  = –11.8 kcal/mol = –49.3 kJ/mol. High ∆Gº  Hydrolysis Compounds. ∆Gº  = –10.3 kcal/mol = –43 kJ/mol.

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Hydrolysis of Glucose-6-Phosphate

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  1. Hydrolysis of Glucose-6-Phosphate ∆Gº = –3.3 kcal/mol = –13.8 kJ/mol

  2. High ∆Gº Hydrolysis Compounds ∆Gº = –14.8 kcal/mol = –61.9 kJ/mol

  3. High ∆Gº Hydrolysis Compounds ∆Gº = –11.8 kcal/mol = –49.3 kJ/mol

  4. High ∆Gº Hydrolysis Compounds ∆Gº = –10.3 kcal/mol = –43 kJ/mol

  5. Phosphate Anhydrides (Pyrophosphates) ∆Gº = –7.3 kcal/mol = –30.5 kJ/mol

  6. Thiol Esters ∆Gº = –7.5 kcal/mol = –31.4 kJ/mol

  7. Thiol Esters Thiol ester less resonance-stabilized

  8. “High-Energy” Compounds • Large ∆Gº hydrolysis • Bond strain (electrostatic repulsion) in reactant • ATP • Products stabilized by ionization • Acyl-P • Products stabilized by isomerization • PEP • Products stabilized by resonance • Creatine-P

  9. “High-Energy” Compounds • “High-energy” compound is one with a ∆Gº below –6 kcal/mol (–25 kJ/mol)

  10. High-Energy Compounds

  11. Group Transfer Potential

  12. Lecture 25 Chemical Sense in Metabolism

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