Introducing perfect skin & THE CLEAR SKIN DIET Acne-free & blemish-free skin - naturally.

1. Introducing perfect skin & THE CLEAR SKIN DIET Acne-free & blemish-free skin - naturally.

2. Healthy Skin • Why is having healthy skin so important? • Your face says a lot about you and your health. And the condition of your skin also affects how you feel about yourself. That’s why you try take care of it, and want it to look its best. Unfortunately, stress, poor dietary choices and hormonal changes can get in the way, leaving you with blemishes, breakouts or acne. • Genuine Health can help you achieve healthy skin at any age. Whether you are looking for anti-aging support, anti-acne support or both, we can help with o3mega+glow, multi+dailyglow and now perfect skin…naturally.

3. Acne – Not a ‘Minor’ Problem • Acne is often dismissed as a self-limiting, ‘cosmetic’ problem that occurs as part of the transition to adulthood. • This is far from reality – the experience of acne can be devastating. • “There is no single disease that causes more psychic trauma, more maladjustment between parents and children, and more general insecurity and feelings of inferiority, and greater sums of psychic suffering than does acne vulgaris.” (Sulzberger & Zaldems. Med Clin North Amer 1948) • Acne is defined as “a disease causing malfunction of the pilo-sebaceous unit characterized by lesions”.

4. Acne - The Process • Increased turnover/production of cells of the oil-producing sebaceous gland. In practical terms, this translates into excessive sebum production. • Increased turnover/production of the cells that line the follicle walls. Normally they supply keratin for the growing hair. In practical terms this translates into obstruction of the canal. • “Propionibacterium acnes”, a species of bacteria that sets up residence in the follicle. While acne can occur in the absence of P.acnes bacteria, it does contribute to blockage and provokes an immune system response which causes inflammation. • These problems can cause follicle rupture and leakage of undesirable bacteria, fats and other gunk into the dermis (the area of skin cells surrounding the follicle) and significant inflammation and oxidative stress (free radical generation) can result.

5. Follicles & Acne Types The Normal Follicle The Open Comedone The Closed Comedone Normal production of Blackhead Whitehead sebum and follicle cells – air reacting with melanin – no reaction with air and melanin The Papule Contents have no where to go – red ‘bump’ from immune reaction The Pustule Inflammation and free radical damage significant – spillover well beyond the follicle

6. More than Superficial • Regardless of age, the impact of acne runs deep. • Higher rates of clinical depression, anxiety, anger, suicidal thoughts. • Self-esteem and confidence in social settings/workplace is decreased. • Mental health impairment scores are higher than those of many other chronic illnesses, including diabetes and epilepsy. (Mallon, et al. Br J Derm 1999)

7. Acne – On the Rise • There have been significant increases in acne through all ages in the last half-century – many adults are now experiencing acne for the first time. • A recent editorial in the journal Cutis referred to acne as a ‘world-wide epidemic’. • The increase in adult acne was reported in a recent article ‘Oh, no! Not at my age!’ - U.S. News and World Report (Nov. 14, 2005). • Almost 20 million US & Canadian adults (>26 years) are diagnosed with acne; millions more do not visit doctors. • Acne rate increases are particularly high among professional women. (Silverberg & Weinberg. Cutis 2001) (Galobardes, et al. Br J Derm 2005)

8. Acne - On the Rise (cont’d) • Increases in acne rates have been reported among populations that traditionally have low rates of acne – e.g. the Inuit of Alberta and the Japanese. • Large scale research in 1964 showed that acne was twice as frequent in North American teens vs. counterparts in Tokyo and Yokohama – today the rates are indistinguishable! • Clearly, genetics cannot explain away the changing rates of acne…environmental influences, including nutrition, emerge as important players. (Hamilton, et al. J Clin Endocrinol Metab 1964) (Takahashi, et al. Health Qual Life Outcomes 2006)

9. Acne – Diet Matters! • Despite dermatologists denying it for years, there is an undeniable relationship between diet and skin. In fact what you eat has a greater impact that any topical skincare product. • Two new Harvard studies have shown a clear relationship between milk consumption and acne. • A large study in the Archives of Dermatology (2002) showed that isolated communities in the Pacific Rim and South America have virtually no signs of acne, despite sharing similar genetics to Westernized neighbors. (Cordain, et al. Arch Derm 2002) (Adebamowo, et al Dermatol Online J 2006) (Adebamowo, et al. J Am Acad Derm 2005) • The 2 common threads among the traditional diets of the acne-free isolated communities? • Low in blood-sugar-spiking, simple carbohydrates. • High in omega-3 fatty acids. (Cordain Arch Derm 2003) (Logan. Arch Derm 2003)

10. The Acne-Diet Connection • A new study in the Journal of the American Academy of Dermatology (2007) supports the population studies and anecdotal reports. • A 12-week, low sugar, high fibre diet significantly improved acne and decreased acne-promoting androgens vs. control diet. • Note: subjects were informed only that the investigation was to examine carbohydrate and protein ratios in the diet – not acne per se. • Patients were encouraged to eat fish, and indeed, polyunsaturated fat intake increased while saturated fat decreased during the intervention. (Smith, et al. J Am Acad Dermatol 2007)

11. Acne & Fish Consumption • An examination of over 1000 teens residing in different areas of North Carolina found those consuming the greatest amounts of saltwater fish and seafood = lowest rates of oily skin, comedones, papules, pustules and acne cysts. • A separate study found that acne patients are less likely to be frequent consumers of fish. Acne patients were twice as likely to consume no fish at all vs. age-matched controls. (Hitch & Greenburg. Arch Derm 1961) (Labadarios, et al. Clin Exp Dermatol 1987)

12. The Problem Diet and nutrition can influence these key causes of acne Stress Oxidative Hormones stress Sebum Inflammation production Low nutrient levels ACNE

13. The Solution

14. perfect skin - Formula

15. Formula Overview • perfect skin joins our other successful healthy skin formulas – o3mega+glow and multi+daily glow – and provides an effective, natural solution for problem skin at any age. • perfect skin is a research-based skin health product containing: • o3mega EPA-concentrate from fish oil, • EGCG from green tea, • Zinc, • Vitamin E, and • Selenium in our id System enteric-coated softgels. • These ingredients address the main causes of acne in order to provide a multi-faceted approach to preventing and reducing acne and other skin blemishes – from the inside out!

16. Formula Overview (cont’d) • Acne is an inflammatory condition and our o3mega EPA provides the anti-inflammatory support required, as well as provides overall skin health improvement. • Beyond its known anti-inflammatory and antioxidant effects, EGCG from green tea also acts as a 5-alpha-reductase inhibitor for the skin and may therefore influence the hormonal aspects of acne. • Studies have shown that Zinc levels are lower in acne patients. Research has shown that elemental Zinc (as gluconate) significantly improved inflammatory acne scores when taken over 2 months. This is the exact form of Zinc in perfect skin. Dreno, et al. Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol 1989;69:541-43.

17. Formula Overview (cont’d) • A number of studies show that the glutathione peroxidase (antioxidant enzyme) activity is low in acne patients. Vitamin E plays a role in proper glutathione peroxidase activity, which is dependent upon Selenium to function. Therefore it is not surprising that low levels of blood Selenium have been documented in acne patients. One study examined the effect of daily Selenium and Vitamin E daily in acne. The combination led to improvements - especially in those with low baseline glutathione peroxidase activity. Micaelsson and Edqvist. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol 1984;64:9-14. • A number of studies show that blood sugar abnormalities may be involved in the promotion of acne. Some have referred to acne as diabetes of the skin. An open label research study found that 400mcg of Chromium improves acne. This is the exact dosage of Chromium found in perfect skin. McCarty. High-yeast chromium for acne? Med Hypotheses 1984;14:307-10.

18. The Pathways perfect skin addresses all the key causes of acne with its synergistic blend of ingredients: Stress (EPA,Selenium) Oxidative stress Hormones (Zinc, Selenium, EGCG) (Zinc, Chromium, EGCG) Sebum production Inflammation (Zinc, EPA, Chromium) (EPA, Zinc, EGCG) Low nutrient levels (Zinc, Selenium, EPA) perfect skin

19. The Misconception • Many consumers make problem skin worse by DRYING it out – either via harsh topicals or over-exfoliation. • This is a vicious circle, as your body compensates by producing more oil which then leads to an increased likelihood of acne. • In addition, over-exfoliated skin is more prone to sun damage and premature aging. • The ideal situation is controlled sebum production – keeping the skin naturally moist and healthy; oily skin is not bad (in fact those with oily skin are much less prone to premature skin aging). • Remember – your skin type is genetic, but your skin condition is within your control!

20. Theperfect skin Solution • By treating the various acne pathways and controlling sebum production, perfect skin provides a non-drying solution to acne. • perfect skin’s ingredients are backed by science in their specific ratios and combinations – isolated ingredients will not work as well as our synergistic formula. • Harsh topicals have numerous downsides including increased sebum production, lesion scarring and premature aging due to skin irritation/dehydration. perfect skin does not – it is your healthy solution for perfect skin!

21. Why EPA? • Studies show that inflammation is one of the earliest events in the development of each acne lesion – it is not merely a consequence of acne. • Cutting off this process can help prevent acne, not just help it heal faster or cover it up. • EPA is well documented to inhibit the production of the inflammatory chemical LTB4. • LTB4 stimulates sebum production. • The synthetic LTB4 blocker Zileuton® reduces sebum fat production by 65% and improves reduces acne lesions by 71%. • Overall symptom reduction with Zileuton® is 59% over 12 weeks. • Head-to-head, EPA from fish oil has been shown to inhibit LTB4 production to the same degree as Zileuton®. Therefore the same symptom reduction rates are expected with fish oil treatment. • Due to its anti-inflammatory affect, EPA-rich fish oil is now considered standard care for the treatment of arthritis. • EPA lowers local platelet activating factor (PAF), a chemical known to stimulate the sebocytes (sebum cells) and otherwise promote inflammation in the pore. Zouboulis, et al. Arch Derm 2003 (Surette, et al. Clin Ther 2003) Campione, et al. Acta Derm Venereol 2006) (Cleland & James. J Rheumatol 2000) (Zhang, et al. Exp Dermatol 2006) (Sperling. World Rev Nutr Diet 1991)

22. Why EGCG from Green Tea? • The green tea catechin EGCG is a strong antioxidant with anti-inflammatory properties. • Acne patients are under increased local and systemic oxidative stress. • In 200 acne patients (vs. age matched controls), lowered blood antioxidant status was associated with severity of acne. • Experimentally, a high-EGCG green tea improves long-term Zinc and selenium status – both are known anti-acne nutrients. • EGCG may also diminish acne through yet other mechanisms – hormonal. • EGCG dampens the conversion of testosterone into dihydrotestosterone (DHT). It slows down the activity of 5α-reductase, the enzyme responsible for conversion. • Synthetic 5α-reductase inhibition (Proscar®) has recently been shown to be helpful in adult acne. • As reported in the Archives of Dermatology (2001), the DHT-lowering effects of EGCG provide therapeutic potential in acne because DHT otherwise stimulates sebum production. (Hamdaoui, et al. Ann Nutr Metab 2005) (El-Akawai, et al. Clin Exp Dermatol 2006) (Shaw. Arch Dermatol 2001) (Kohler, et al. Gynecol Endocrinol 2007)

23. Why Zinc? • A number of studies over the last 30 years have shown that zinc levels are low in acne patients vs. healthy controls. • Lower zinc levels are also associated with severity of acne. • This is not surprising as zinc is an antioxidant and anti-inflammatory nutrient for the skin, and zinc is also involved in the metabolism of omega-3 fatty acids. • Therefore demands for zinc are increased when inflammation in the skin is apparent. • Separate studies have shown that both oral and topical zinc is helpful in the reduction of acne lesions. • Research shows particular improvement in lesions with marked inflammation over 2 months of care vs. placebo. • It Zinc helps to clear away and break down substance P, a nerve chemical which promotes sebum production under stress. (Amer, et al. Int J Dermatol 1982) (Dreno, et al. Acta Derm Venereol 1989) (Dreno, et al. Eur J Dermatol 2005) (Schwartz, et al. Dermatol Surg 2005) (Toyoda & Morohashi. Dermatol 2003)

24. Why Selenium? • As mentioned, acne patients are under increased oxidative stress. • In particular, the antioxidant enzyme glutathione peroxidase activity is low in acne patients. • Glutathione peroxidase (GPx) is entirely dependent upon selenium for its function. • Like chromium, it may be involved in blood sugar regulation. • Low levels of blood selenium have been documented in acne. • Intervention study showed that selenium improved acne over the course of 12 weeks, particularly in those with low GPx at baseline. • It is likely that oxidative stress in acne places greater demands on selenium for antioxidant pathways. (Beckett & Arthur. J Endocrinol 2005) (Juhlin, et al. Acta Derm Venereol 1982) (Micaelsson. Acta Derm Venereol 1990) (Micaelsson & Edqvist. Acta Derm Venereol 1984)

25. Why Chromium? • Blood sugar elevations, or poor control of blood sugar has been connected to acne for decades. • Large population studies suggest that traditional diets low in blood sugar-spiking foods (i.e. a low glycemic-load diet) are protective against acne. • Rapid delivery of sugar to the skin may cause sustained elevations in skin sugar among acne patients. • After glucose tolerance test, skin sugar levels stay high in acne for >225 minutes (norm is 60 minutes) • Elevated sugar can promote inflammation and oxidative stress (both of which are causes of acne). • Early investigations showed that oral diabetic medications improved acne in non-diabetic patients. • One group commented in the Canadian Medical Association Journal (1958) that acne might be ‘diabetes of the skin’. • Preliminary study showed significant improvement in acne with oral chromium supplementation, likely due to its affect on blood sugar control. (Smith, et al. J Am Acad Dermatol 2007) (McCarty. Med Hypotheses 1984) (Cordain. Semin Cutan MedSurg 2005)

26. Stress & Acne • A relationship between stress and acne has been suspected and discussed in dermatology textbooks since the 1940s. • New research has supported the acne-stress connection. • Exam stress, work stress, relationship stress have all been tied to exacerbation of acne. • Under psychological stress, dietary habits are altered - increased consumption of sugar and saturated fat, decreased fruit and vegetable intake. • The body has a greater demand for zinc and selenium under stress – both of which perfect skin provides and as a result, lessens the rate of stress-related acne. (Chiu, et al. Arch Dermatol 2003) (Sahin, et al. Pharmazie 2004)

27. Stress & Acne (cont’d) • Psychological stress promotes both oxidative stress and inflammation. • In the presence of oxidative stress/inflammation, there is greater turnover and demand for omega-3 fatty acids. • Omega-3 fish oil has been shown to lower the stress hormone cortisol and increase resilience to stress. • Experimentally, EGCG lowers stress and decreases anxiety. • In women, stress increases both testosterone and the stress hormone cortisol. EPA and EGCG from green tea can lower cortisol and testosterone under stress. • Therefore both EGCG and EPA as found in perfect skin lessen stress-related acne rates as well! (Vignes, et al. Brain Res 2006) (Michaeli, et al. Clin Nutr 2007)

28. perfect skin& Mental Outlook • In addition to the direct influence on the acne pathways, the ingredients in perfect skinalso have potential to regulate mental outlook. • Anxiety, depression and anger are all associated with the acne experience. • It could also be that the same nutritional deficits (i.e. lack of omega-3, zinc, selenium, chromium) set a much higher risk of psychological changes. • Low levels of omega-3, zinc, selenium and chromium have all been linked (individually) with depression, anxiety and anger. • The addition of anxiety-reducing EGCG to the EPA, zinc, selenium and chromium adds to the synergistic mood-regulating effects of perfect skin. (Katzman & Logan. Med Hypotheses 2007)

29. Expectations In summary, based on clinical research, consumers can expect the following results with perfect skin: • Reduction in acne lesion and blackhead/blemish count. • Reduction in inflammation of acne lesions and blackheads/blemishes. • Decreased sebum production, follicle blockage. • Prevention of acne lesion and blackhead/blemish formation. • Normal structure, size and function of pores (note: once oil gets in the follicle and pores stretch, they do not “spring back” so prevention is key!) • Enhanced results with conventional approaches to acne and other blemishes. • Increased resilience to stress and regulation of mood. NOTE: Results can be expected in as little as 4 weeks (average is 1–3 months).

30. perfect skin • “Acne is not just a teenage concern, but a growing health problem across all ages. The perfect skin formula provides a superior, natural and effective solution, as it works beneath the skin surface where acne starts.” Dr. Alan Logan, FRSH, ND

31. Safety & Dosages • The ingredients in perfect skin have been carefully selected to provide adequate amounts of the therapeutic nutrients. • Recommended dose: • To reduce acne flare-ups: Adults aged 14 & older: Take two (2) softgels, twice daily with meals. • To prevent acne: Adults and children aged 12 & older: Take two (2) softgels daily, with meals. • perfect skin helps to reduce and prevent acne and other skin blemishes, as well as control them through anti-inflammatory action. • perfect skin uses o3mega pharmaceutical grade, molecularly distilled, wild fish oil that is free of all toxins including mercury and PCBs. • Caution: Not to be taken during pregnancy, while breastfeeding, by those on Tetracyclines or with a history of non-melanoma skin cancer unless under the recommendation of a health care practitioner.

32. THE CLEAR SKIN DIET • To support the launch of perfect skin, we are thrilled to introduce a cutting edge book co-authored by Genuine Health’s leading Naturopathic Doctor, Alan C. Logan ND, and renowned Holistic Dermatologist Valori Treloar, MD. • The book provides an in-depth look at the acne process itself, its causes, presentation, conventional and dietary treatments. • Historical aspects are detailed, including the research follies of the 1970s that relegated diet as an unimportant consideration. • However, the focus is on nutritional medicine, with detailed explanations on the therapeutic value of anti-inflammatory and antioxidant-rich foods and nutrients. • Nutritional influences on acne-promoting hormones are described. • The relationship between gut health and clear skin is covered, as is the stress-acne connection.

33. FAQs • Can I take perfect skin with multi+daily glow or o3mega+glow? • Yes. One can safely take all 3 products together, but due to the EPA contained in both o3mega products, it is recommended to choose one of theo3megas, and then add multi+daily glow. The lycopene in multi+daily glow can improve the acne results achieved with perfect skin so this is an idea combination! • How does perfect skin work vs. topical acne/blemish products? • Topicals generally treat acne by DRYING out the skin, which can lead to dull, dehydrated and prematurely aged skin. perfect skin addresses sebum production from the inside out, and results in clear, hydrated skin. This makes perfect skin particularly unique and especially appealing to adult acne sufferers. • How does perfect skin compare to Accutane®? • Like perfect skin, Accutane addresses many of the major processes behind the development of acne – prevents overgrowth of the sebaceous gland, lowers sebum production, normalizes the overproduction of the cells from the follicle lining, has antioxidant and anti-inflammatory activity. HOWEVER, unlike Accutane, perfect skin does not cause fetal malformations, and is not associated with depression, suicide, inflammatory bowel, cerebral ischemia, dental decay, menstrual irregularities, peripheral nerve dysfunction, night blindness,panic attacks, bone loss, increased triglycerides and cholesterol, and B12 and folate deficiency.