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Trial Selection Process

Trial Selection Process. Jingjing Zhang, et al. JAMA. 2006;296:1619-1632. Included Trials of Rofecoxib*. Jingjing Zhang, et al. JAMA. 2006;296:1619-1632. Included Trials of Celecoxib*. Jingjing Zhang, et al. JAMA. 2006;296:1619-1632. Included Trials of Valdecoxib and Parecoxib*.

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Trial Selection Process

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  1. Trial Selection Process Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  2. Included Trials of Rofecoxib* Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  3. Included Trials of Celecoxib* Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  4. Included Trials of Valdecoxib and Parecoxib* Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  5. Included Trials of Etoricoxib and Lumiracoxib Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  6. Descriptive Characteristics of Included Randomized Double-Blind Clinical Trials of Cyclooxygenase 2 Inhibitors Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  7. Number of Arrhythmia Events by Reported Subtypes Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  8. Overall Relative Risks of Renal and Arrhythmia Events, Cyclooxygenase 2 Inhibitors vs Controls Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  9. Relative Risk of Composite Renal Events (Renal Dysfunction, Peripheral Edema, Hypertension) by COX-2 Inhibitors, Meta-Regression Stratified by Study Characteristics Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

  10. Time-Cumulative Analysis of Rofecoxib and Risk of Renal and Arrhythmia Events Sensitivity analyses of the 9 trials with 20300 participants (10126 drug, 10174 control group) and 15 arrhythmia events (13 drug, 2 control group) without half-integer correction using sparse-events exact methods: Fisher exact test P =.004, and Mantel-Haenszel pooled relative risk 6.52 (95% CI, 1.48-28.8; P=.004) Jingjing Zhang, et al. JAMA. 2006;296:1619-1632

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