2011 년 1 분기 정리

1. 2011년 1분기 정리 화순전남대학교병원 미토콘드리아 연구실 (Molecular Diagnostics and       Mitochondrial Research Laboratory) http://www.mtdna.or.kr 2011. 04. 11 (월)

2. Molecular Diagnostics and Mitochondrial research laboratory Treatment Outcome Hematopoietic Stem cells Hematopoietic Ds MRD determination Biomarkers Chronic Degenerative Diseases Potential new therapeutics New molecular Pathophysiology Cancer/Aging Diagnosis www.mtDNA.or.kr

3. 정리 내용 • 연구원 동정 • 학술대회 참가 및 초록발표 • Accepted manuscript • 준비중인 SCI논문 • 연구과제 수행

4. 2011년 MTDNA연구팀연구원 동정 현재 신명근 교수님, 김혜란, 김환영, 김민영연구원 • 2010. 08. 01 김민영 연구원 실험실 합류 • 2010. 11. 17 안애자, 엄하영 선생님 논문 심사: 우수한 논문내용으로 통과 • 2010. 12. 01 오지연 연구원 여수전남병원 입사 • 2010. 12. 02~09 신명근 교수님, 미국 혈액학회 (올랜도, 미국) 참석 및 연제발표( 혈액학회 지원) • 2010. 12. 16~18 김혜란 박사, 아시아미토콘드리아 학회 (큐슈, 일본)참석 및 연제발표 (BK21 사업단 지원) • 2011.01.19 미토콘드리아 실험실 홈페이지 구축 (www.mtdna.or.kr) • 2011.02.05 김환영 연구원 광주보건대학 전공심화과정 졸업 • 2011. 02.25 안애자, 엄하영 선생님 석사 졸업 • 2011.03.01 김혜란 박사님 BK 의생명 인력사업단 Post-Doc 3년차 재계약 • 2011. 03. 05 김민영 연구원 광주보건대학 전공심화과정 입학

5. 2011 학술대회 참가 및 초록제출 1) Korea-Germany International Joint Symposium- 2011.03.04 화순전남대학교 병원 대강당 ‘Molecular diagnostics and mitochondrial research in cancer and chronic inflammatory diseases’ 2) 미토콘드리아허브제어연구센터 초청강의 - 2011.03.24 부산 동아의대 ‘Translational Mitochondrial Research in Hematopoietic and Chronic Inflammatory Diseases’ 3) 2011 ISLH, New Orleans, Louisiana (2011.5.6-8) - Mitochondrial DNA copy number and hnRNP A2/B1 protein are biomarkers for benzene itself-related toxicity and hematotoxicity - Metformin selectively kills the AML stem cells through increased phosphorylation of AMP-activated protein kinase - The spectrum of mitochondrial genome instability in acute myeloid leukemia and leukemia stem cells 4) 2011 IGCC, 서울 코엑스 (2011. 4.20-23) - Mitochondrial genome instability in barrett's esophagus associated with increased production of reactive oxygen species

6. 2011 ACCEPTED MANUSCRIPT 1) Multilocus Sequence Typing for Candida albicans Isolates from Candidemic Patients: Comparison with Southern Blot Hybridization and Pulsed-field Gel Electrophoresis Analysis. Korean J Lab Med. 2011 Apr;31(2):107-14 2) Donor cell origin of multiple myeloma occurring after allogeneic haematopoietic stem cell transplantation in a patient with refractory anaemia with ring sideroblast. J Clin Pathol. 2011 Mar;64(3):265-8 3) 8p11 myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: A case report and review of the literature. Leuk Res. 2011 Jan 14. [Epub ahead of print] 4) Engineering and Visualization of Bacteria for Targeting Infarcted Myocardium. Mol Ther. 2011 Mar 1. [Epub ahead of print]

7. 5) Genome-wide high density single-nucleotide polymorphism array-based karyotyping improves detection of clonal aberrations including der(9) deletion, but does not predict treatment outcomes after imatinib therapy in chronic myeloid leukemia. Ann Hematol. 2011 Mar 8. [Epub ahead of print] 6) Treatment outcome of all-trans retinoic acid/anthracycline combination chemotherapy and the prognostic impact of FLT3/ITD mutation in acute promyelocytic leukemia patients. Korean J Hematol. 2011 Mar;46(1):24-30 7) Biofilm formation and genotyping of Candida haemulonii, Candida pseudohaemulonii, and a proposed new species (Candida auris) isolates from Korea Med Mycol. 2011 Jan;49(1):98-102

8. 2011 SUBMITTED MANUSCRIPT, UNDER REVIEW • Mitochondrial DNA copy number and hnRNP A2/B1 protein are biomarkers for direct exposure of benzene itself Environmental toxicology and chemistry(under review) • Distinctive Hematological Abnormalities in East Asian Neonates and Children with Down Syndrome. Int J Lab Hematol. Nov 30, 2010 accepted (under publication) • Spectra of Chromosomal Aberrations in 325 Leukemia Patients and Implications for the Development of New Molecular Detection Systems. Journal of Korea Medical Science. (under review) • Plasma proGRP concentration is sensitive and specific for discriminating small cell lung cancer from nonmalignant conditions or non-small cell lung cancer . Journal of Korea Medical Science. Accepted (2011.05.Publication)

9. 2011 Manuscript preparation • Association of allelic expression imbalance of JAK2 V617F mutation and phenotypic diversity in MPN: • 김혜란/신명근 • 2) Prohibitin as a new biomarkers of leukemia for diagnosis, predicting prognosis, MRD monitoring and • molecular therapeutics: 김혜란/신명근 • Alteration of Mitochondrial Genome and its Pathophysiologial Role in Barrett’s Esophagus : • 김혜란/ 김환영/신명근 • 4) The spectrum of mitochondrial genome instability in acute myeloid leukemia and leukemia stem cells: • 김혜란/ 김환영/안애자/신명근 • 5) mtDNA instability in colon cancer: 김혜란/임상우/김환영/신명근 • Metformin selectively suppressed the proliferation of AML stem cells through increased phosphorylation • of AMP-activated protein kinase : 김혜란/ 엄하영/신명근 • 7) Serum fibrin degradation product is a valuable tumor marker for multiple myeloma: 김혜란/ 최현정/신명근 •  9) Mitochondrial minisatellite alterations in single AML stem cells associated with vicious cycle • hypothesis : 김혜란/ 김민영/김환영/신명근 • 8) Accuracy improvement for glucometer by reducing the hematocrit dependency using informatics • technology

10. 2011 연구과제 수행 • 환경성 질환연구센터 3세부과제 • 한국연구재단(2월) 중견연구자사업 2011 연구과제 프로포셜 • 한국연구재단 중견연구자사업 • 한국연구재단 해외우수연구소유치사업 • 보건산업진흥원 차세대유전체사업(센터사업)

11. 독일 프라운호퍼연구소 Dr. Stolzing과 함께~ Matching partner discussion 잘했어요, 고맙습니다, 아름다워요, 사랑하고 존경하면 세상은 더 아름다워집니다. 감사합니다~