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Piruvat Karboksilase

Piruvat Karboksilase. Kelompok III Endah Nur Endah (10505048) Gaos Mulyawan (10505050) Wiwit Kurniasih (10505054) Liza Gayatri (10505058) Agustina Berliana (10505060) Andi M. Rusli (10505062). Piruvat karboksilase enzim dari kelas ligase → protein mitokondria

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Piruvat Karboksilase

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  1. Piruvat Karboksilase Kelompok III Endah Nur Endah (10505048) Gaos Mulyawan (10505050) Wiwit Kurniasih (10505054) Liza Gayatri (10505058) Agustina Berliana (10505060) Andi M. Rusli (10505062)

  2. Piruvat karboksilase • enzim dari kelas ligase →protein mitokondria • enzim dalam siklus TCA dan glukoneogenesis • mengandung gugus biotin prostetik • memerlukan Mg atau Mn dan asetil-CoA untuk aktif • terbentuk di hati • tergantung oleh ATP

  3. Struktur enzim piruvat karboksilase :

  4. Biotin gugus prostetik Piruvat karboksilase yang mempunyai 5 rantai karbon dengan terminal karboksil adalah ikatan amida dengan gugus asam amino lysine

  5. Reaksi yang terjadi • biotin + ATP + HCO3- → carboxybiotin + ADP + Pi • carboxybiotin + pyruvate → biotin + oxaloacetate

  6. Piruvat karboksilase juga aktif secara allosterik oleh asetil Coenzim A

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