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Origin of Complex Life

Origin of Complex Life. HON-3230 Chance, Emergence or Design. From a Simple Replicator. Life requirements Information storage Replication Metabolism Possible first replicators Protein first world RNA world Lipid world Metabolism first. Metabolism Recapitulates Biogenesis.

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Origin of Complex Life

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  1. Origin of Complex Life HON-3230 Chance, Emergence or Design Steven Gollmer Cedarville University

  2. From a Simple Replicator • Life requirements • Information storage • Replication • Metabolism • Possible first replicators • Protein first world • RNA world • Lipid world • Metabolism first Steven Gollmer Cedarville University

  3. Steven Gollmer Cedarville University

  4. Metabolism Recapitulates Biogenesis • Central Metabolic cycle (A) • Basic replication • Pathway for fatty acid production • Amino acid production (B) • Synthesis involving nitrogen • Basis for protein structure (C) • Synthesis involving sulfur • Basis for nucleic acid and coenzymes (D) • Synthesis involving ring closure Steven Gollmer Cedarville University

  5. Bottom-Up (Modification by co-option) Top-Down (Interoperating components) C S A B N O H N C A O C D B H S C D Two Ways to Model the Essentials Steven Gollmer Cedarville University

  6. Irreduceable Complexity • What are the chances that all the components of a simple device come together in a functional manner? Steven Gollmer Cedarville University

  7. Critique of IC • https://www.youtube.com/watch?v=4dQJzj2DMrA • https://www.youtube.com/watch?v=K_HVrjKcvrU Steven Gollmer Cedarville University

  8. Complexification of Cells • Autotrophs • Photoautotrophs • Lithautotrophs • Thermophilic autotrophic bacteria • Heterotrophs • Need environmental organic compounds • Prokaryotes • Circular DNA Steven Gollmer Cedarville University

  9. Beginning of Eukaryotes • Endosymbiosis Theory • Lynn Margulis • Presence of Organelles • Mitochondria • Chloroplasts • Nucleus • Contain genetic material Steven Gollmer Cedarville University

  10. Additional Changes • Animals vs. Plants • Cell membrane vs. cell wall • Plastids • Origin of Sex • 2 fold cost over parthenogenesis • DNA repair mechanism • Mitosis vs. Meiosis Steven Gollmer Cedarville University

  11. Common Ancestry Steven Gollmer Cedarville University

  12. Molecular Ancester • DNA Mutation • Molecular Phylogeny • Molecular Clock • Prediction • Common animal 0.9 - 1.0 billion YBP • Problem • Different trees for different indicators • Lateral Gene Transfer Steven Gollmer Cedarville University

  13. Cambrian Explosion Steven Gollmer Cedarville University

  14. Darwinian Evolution Punctuated Equilibrium Actual Discontinuity Steven Gollmer Cedarville University

  15. Paper 3 – Synthetic Biology • Craig Venter • Bacteria Genome Press Release (Handout) • Web Site – http://www.jcvi.org/cms/home/ • Synthetic Biology • Web Site - http://syntheticbiology.org/ • Bio-Bricks - http://biobricks.org/ • iGEM Competition - http://www.igem.org/Main_Page • Write an essay analyzing the benefit of synthetic biology and its value to the creationist community. (No false praise) • Include 3 developments in this area with references to support your claims. • 5 points are reserved for clarity and significance of your analysis. Steven Gollmer Cedarville University

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