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BLUE PEOPLE OF KENTUCKY

BLUE PEOPLE OF KENTUCKY. We’re not talking about. The smurfs Clinically depressed people Fans of B.B. King The Blue Man Group Avatarians.

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BLUE PEOPLE OF KENTUCKY

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  1. BLUE PEOPLE OF KENTUCKY

  2. We’re not talking about... • The smurfs • Clinically depressed people • Fans of B.B. King • The Blue Man Group • Avatarians

  3. Ingesting elemental silver can also turn the skin blue. This man, Paul Karason, rubbed colloidal silver on his face and skin many years ago to treat a skin condition, which made him slowly turn a bluish/grey color.

  4. WHO ARE THEY? "Blue People" are descendants of Martin Fugate, who suffered from a recessive gene which limits or stops the production of the enzyme diaphorase (enzymes that catalyze the reduction of various dyes to act as hydrogen acceptors NADH + NADPH).

  5. What makes them blue? • Methemoglobinemia • Red blood cells (RBC) from blue people are deficient in NADH diaphorase activity and cannot reduce the oxidized iron in methemoglobin (metHb).

  6. The lack of this enzyme gives people a blueish cast to their skin rather than pink. Lack of oxygen to RBC gives this color.

  7. Interview • '"He was almost purple,"' his father, Alva Stacy, recalls." Benjy was born in a maternity ward near Hazard, Kentucky and was rushed by ambulance to a medical clinic in Lexington to find help for his blue problem. Days of testing provided no answers; but then Benjy's grandmother told the doctor a story about the "blue" Fugates. Incredibly, Benjy had inherited a gene dating back over 162 years! Thankfully, Benjy lost his blue shade after a few weeks and the only lingering effects were blue fingernails and lips when he was cold or angry.

  8. Fugate FamilyFather + 4 children are blue

  9. Luna Fugate and John Stacey

  10. Lorenzo Dow Fugate and Eleanor Fugate. Lorenzo Dow was also know as "Blue Anze"

  11. Real Folks

  12. Of Lonesome Creek, Kentucky

  13. In Hazard, the County Seat

  14. Symptoms • Blue colored skin • Headaches • Fatigue • Coma • Death

  15. Treatment • The homozygous patient (bb) daily ingestion of ascorbic acid to increase non- enzymatic reduction of methemoglobin • or the use of methylene blue (oddly enough)- acts as an e- donor

  16. Degree of Blueness • BB for the normal allele – not blue • Bb - heterozygotes for the blue trait - do contain some NADH diaphorase activity –(blue lips, blue fingernails) • bb– homozygous recessive - blue skin

  17. Blue Pedigree of FugatesGet Handout  • = male with it • = female with it

  18. Pedigree Symbols

  19. More Pedigree Symbols

  20. Found on WikiPedia: There is a mistake here. Can you find it? bb Bb BB

  21. Pedigree of Fugates • Can you work out the genotypes?

  22. Pedigree with Genotypes • trait visible • carrier

  23. PRINT AND COLOR

  24. Pedigree Videos • Media Showcase: Pedigree • Understanding Pedigrees (6:41) • Solving a Pedigree - the Fast Way (example 1) (6:42) • Solving a Pedigree The Fast Way -example 2(6:46)

  25. You Will Make a Pedigree of Your Own Family GET INSTRUCTION SHEET Choose a trait from the lab of Variations of a Human Face (the one you drew the face on)

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