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Reviews: update Hamerman, J. A., Ogasawara, K., Lanier, L. L. (2005).

Reviews: update Hamerman, J. A., Ogasawara, K., Lanier, L. L. (2005). NK cells in innate immunity. Curr Opin Immunol 17, 29-35. W.M. Yokoyama and S. Kim (2006). Licensing of natural killer Cells by self-major histocompatibility complex class I. Immunol. Rev. 214, 143-154.

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Reviews: update Hamerman, J. A., Ogasawara, K., Lanier, L. L. (2005).

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  1. Reviews: update Hamerman, J. A., Ogasawara, K., Lanier, L. L. (2005). NK cells in innate immunity. Curr Opin Immunol 17, 29-35. W.M. Yokoyama and S. Kim (2006). Licensing of natural killer Cells by self-major histocompatibility complex class I. Immunol. Rev. 214, 143-154. J.G. Sambrook and S. Beck (2007). Evolutionary vignettes of natural killer cell receptors. Curr. Op. Immun. 19. 553-560 E. Tupin, Y. Kinjo and M. Kronenberg (2007). The unique role of natural killer T cells in the response to microorganisms. Nat. Rev. Microbiol. 5, 405-417. H.-G. Ljunggren and K.-J. Malmberg (2007). Propsects for the use of NK cells in immunotherapy of human cancer. Nat. Rev. Immun. 7, 329-339.

  2. Genomic localization Chr19 LRC Chr12 NKC Recent evolution human - mouse: convergent evolution Interactions MHC and MHC-like proteins Polymorphisms

  3. chr chr

  4. The human NKC

  5. Konvergente Evolution: 2 unterschiedliche Rezeptorklassen für gleiche Funktion In Mensch und Maus keine funktionellen KIR´s keine funktionellen Ly49

  6. NKG2-D and stress / viral infection / tumors 3 Liganden hochreguliert bei Stress, Virusinfektion, in Tumorzellen: MIC-A, -B RAEs ULBPs CMV immune evasion strategies

  7. HCMV: reguliert MHC class I hinunter UL40 Peptid bringt HLA-E wieder hoch / inhibitive CD94/NKG2A Interaktion UL18 ist MHC class I mimic / KIR Interaktion

  8. HCMV: UL16 inhibiert ULBP und MIC Interaktion mit NKG2D

  9. Some new concepts: NK cells and dendritic cells NK/T cells NK cells and tumors Acquisition of receptor repertoire

  10. „NK“ receptors on T lymphocytes and other cell types KIR und CD94/NKG2A /NKG2C: nur NK cells und Subpopulations von NKT cells ILT, LAIR, NKG2D: auch auf anderen Leukozyten Monocyten, Makrophagen, dendritischen Zellen, B Zellen

  11. Acquisition of receptor repertoire Hypothesis: NK cell education (not really understood) each NK cell has several inhibitory and activating receptors, developing NK cell initiates inhibitory receptor gene expression in a sequential, cumulative and stochastic fashion class I deficient mice: NK cells are tolerant „at least one“ hypothesis: formation of repertoire regulated such that „at least one“ inhibitory receptor for one or another self MHC is present

  12. Possibility: first stimulatory receptors, induce expression inhibitory receptors until zero sum between stimulation and Inhibition Question: NK cells are alloreactive but self-tolerant, how ??

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