Amino Acids as Protein Building Blocks

1. Amino Acids as Protein Building Blocks

2. Proteins are naturally-occurring biopolymers comprised of amino acids. The biological function of proteins is inherent in their three dimensional structure. All the information required for correct folding of the protein into its functional native structure is contained in the primary sequence of amino acids. The physical chemical properties of the amino acids contain the biological information required for folding and function.

3. 1 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPD QQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76 Structure of Ubiquitin By convention the primary sequence of amino acids is listed left to right from the amino terminus to the carboxyl terminus.

4. Fundamental Structure of Amino Acids Amino acids are most logically grouped according to the physical properties of their side chains.

5. Aliphatic Amino Acids

6. Aromatic Amino Acids

7. Polar Amino Acids

8. Disulfide Bond Formation

10. Acidic Amino Acids

11. Mechanism of Asn/GlnDeamidation

12. Basic Amino Acids

14. R74 D39 R72 R42 K27 E51 D52 E24 R54 K6 D58 K48 E18 E64 K63 Representations of Protein Surfaces