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Sleep, and Memory formation

Sleep, and Memory formation. Memory Consolidation. Trace Reactivation. Slow wave Sleep. Sleep, and Memory formation. Memory Consolidation. At the time of encoding, memories are susceptible to disruption. With time, they become robust to interference (Mueller and Pilzecker, 1900)

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Sleep, and Memory formation

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  1. Sleep, and Memory formation Memory Consolidation Trace Reactivation Slow wave Sleep

  2. Sleep, and Memory formation Memory Consolidation At the time of encoding, memories are susceptible to disruption. With time, they become robust to interference (Mueller and Pilzecker, 1900) Cerebral trauma leads to a greater loss of recent than remote memories (Ribot, 1882)

  3. Sleep, and Memory formation SLEEP Non-REM REM Stages 1 2 3 4 Spindles Slow wave,delta

  4. Sleep, and Memory formation

  5. Sleep, and Memory formation Slow-wave sleep Slow waves (a.k.a up/down states) Neuroscience 137 (2006) 1087–1106 GROUPING OF BRAIN RHYTHMS IN CORTICOTHALAMIC SYSTEMS M. STERIADE* Laboratory of Neurophysiology, Laval University, Faculty of Medicine, Quebec, Canada G1K 7P4

  6. Sleep, and Memory formation Is there evidence for trace replay theory? … when neural activity patterns seen during a task are ‘replayed’ during subsequent periods of inactivity

  7. Sleep, and Memory formation Reactivation • In rats, hippocampal activity patterns during behavior are related to patterns during subsequent periods of inactivity(Pavlides and Winson, 1989; Wilson and McNaughton, 1994), • specifically, in hippocampal oscillations (Kudrimoti et al., 1999) • demonstrated to co-occur with slow-waves (Sirota et al., 2003; Battaglia et al., 2004) • seen in the hippocampus and neocortex of rats (Qin et al., 1997; Ribeiro et al., 2004; Ji and Wilson, 2007) • seen in non-human primate, in multiple ‘disconnected’ sites, coordinated across hemispheres. (Hoffman and McNaughton, 2002) • seen in other structures, maybe under other names (Arieli, Yuste/MacLean, Dan)

  8. The upshot of up states in neocortex: From slow oscillations to memory formation Memory Consolidation Trace Reactivation Slow wave Sleep

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