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The development of nervous system. 陳建榮. http://web.nchu.edu.tw/pweb/users/chenjr/. Nervous system: Central nervous system (CNS): brain, spinal cord Peripheral nervous system (PNS): cranial nerves, spinal nerves Autonomic nervous system (ANS). Origin of nervous system.
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The development of nervous system 陳建榮 http://web.nchu.edu.tw/pweb/users/chenjr/
Nervous system: • Central nervous system (CNS): • brain, • spinal cord • Peripheral nervous system (PNS): • cranial nerves, • spinal nerves • Autonomic nervous system (ANS)
Origin of nervous system • Neutralization: • Notochord • Neural plate • Neural groove • Neural tube, neural crest • Rostral neuropore, caudal neuropore
Neual tube: • Neural canal central canal • Neuroepithelial cell (pseudostratified columnar epi) • Ventricular zone • Intermediate zone • Marginal zone • Alar plate dorsal horn • Basal plate ventral horn • Roof plate • Floor plate • Mesenchyme spinal meninges • Dura matter • Arachnoid • Pia matter
Positional changes of spinal cord 8 weeks 24 weeks child adult
Congenital anomalies of spinal cord Neural tube defects (NTD)
Spinal bifida oculta隱性脊柱雙裂 Spinal bifida cystica脊柱雙裂囊腫 Spinal bifida cystica脊柱雙裂囊腫 Myeloschisis脊髓裂
Development of brain • 3 primary vesicles: • Forebrain (prosencephalon) • Telencephalon - cerebral hemispheres • Diencephalon - thamaus • Midbrain (mesencephalon) • Mesencephalon - midbrain • Metencephalon - pons, cerebellum • Myelencephalon - medulla • Hindbrain (rhombencephalon)
Brain flexures腦彎 • Midbrain flexure • Cervical flexure • Pontine flexure
Myelencephalon(medulla) Caudal portion Rostral portion
Alar plate • Special somatic afferent (SSA) • CN VIII (hear, vestibular) • General somatic afferent (GSA) • CN V • Special visceral afferent (SVA) • CN VII, IX, X (taste) • General visceral afferent (GVA) • CN X • Basal plate: • General visceral efferent (GVE) • CN IX, X • Special visceral efferent (SVE) • CN V, VII, IX, X • General somatic efferent (GSE) • CN III, IV, VI, XII
Pituitary gland: • Adenohypophysis (oral ectoderm) • Hypophysial pouch • Pars tuberalis • Pars distalis • Pars intermedia • Neurohypophysis (neural ectoderm) • Neurohypophysial bud • Pars nervosa • Infundibular stem • Median eminence
13 weeks 21 weeks 32 weeks
38 weeks 25 weeks
Early stage of nervous system • Proliferation • Migration • Differentiation • Organization
Choroid plexus Cerebrospinal fluid (CSF)
Hydrocephalus 水腦 - excessive formation of CSF - blockage of the circulation of CSF - diminished absorption of CSF