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Chapter 11

Chapter 11. Peripheral Nervous System. Peripheral Nervous SystemOutline. Introductory Comments 1. Autonomic Nervous System Parasympathetic versus sympathetic nervous systems 2. Somatic Nervous System 3. Adrenal Gland & Modified ANS 4. Chemical Anatagonists & Agonists 5. Neurotoxins.

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Chapter 11

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  1. Chapter 11 Peripheral Nervous System

  2. Peripheral Nervous SystemOutline • Introductory Comments • 1. Autonomic Nervous System • Parasympathetic versus sympathetic nervous systems • 2. Somatic Nervous System • 3. Adrenal Gland & Modified ANS • 4. Chemical Anatagonists & Agonists • 5. Neurotoxins

  3. ANTAGONISTIC

  4. Exception to the rule • 1. Sweat gland and vascular smooth muscleonlysympathetic innervation • 2. Cooperativity between sympathetic and parasympathetic

  5. Autonomic Nervous System Controls • Found in Smooth Muscle • Found in Glands • Found in Cardiac muscle

  6. sympathetic and parasympathetic neurons differ in several ways. • Site of ganglion • Length of pre and post-ganglionic fibers • Type of neurotransmitters released • pharmacologically

  7. model of the autonomic pathway “intrinsic neurons modulate” Divergence can occur

  8. Autonomic Nervous System Length of the fibers Spinal cord Parasympathetic Sympathetic Sympathetic Adrenal Medulla release primarily Epi.

  9. Autonomic Nervous SystemNeurotransmitters Ganglion in circles Parasympathetic Ach Ach TISSUE Ach Sympathetic Spinal cord NE Sympathetic Ach Adrenal Medulla release primarily Epi.

  10. Autonomic Division of Acetylcholine Receptor

  11. Autonomic Division of Adrenergic Receptor

  12. Muscarinic Nicotinic Atropine, scopolamine Alpha-bungarotoxin (at muscle only, curare) Cholinergic Antagonists

  13. Alpha Beta Alpha blockers Beta blockers: propranolol (B1 and B2) and metaprolol is B1 only Adrenergic Antagonists

  14. Somatic Nervous System Ach Somatic Neuromuscular Junction Always Excitatory!

  15. Single neuron!

  16. Let’s take a minute to look at the unique adrenal gland.

  17. What other structure that we studied has two different embyronic origins?

  18. Summary

  19. Natural neurotoxins TTX blocks Na+ channels Funnel web spider, Agelenopsis aperta Blocks voltage gated Ca++ Bungarus multicinctus Blocks Acetylchoine receptors Fish hunting cone snail, Conus geographus Block Ca++ channels

  20. Blocks exocytosis • Botulism Toxin

  21. Botox

  22. Stimulant • Binds to acetylcholine receptors Acetylcholine receptor

  23. Summary: Effect of ANS on Various Physiological Systems

  24. THE END

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