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Short Bowel Syndrome. Dr. TAMER M. ABD ELRHMAN. Short Bowel Syndrome. Presence of less than 200cm of residual small bowel in adult . Functional definition: - insufficient intestinal absorptive capacity results in: Diarrhea. Dehydration. Malnutrition. . AETIOLOGY. In adult:
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Short Bowel Syndrome Dr. TAMER M. ABD ELRHMAN
Short Bowel Syndrome • Presence of less than 200cm of residual small bowel in adult. • Functional definition: - insufficient intestinal absorptive capacity results in: • Diarrhea. • Dehydration. • Malnutrition.
AETIOLOGY In adult: • Acute mesenteric ischemia • radiation enteritis • Malignancy • Crohn’s disease In pediatric: • Intestinal atresias • Volvulus • Necrotizing enterocolitis
PATHOPHYSIOLOGY • Presence or absence of an intact colon (capacity to absorb fluid & electrolytes and absorb short-chain FA). • Intact ileo-cecal valve. • A healthy, rather diseased residual small intestine is associated with decreased severity of malabsorption. • Resection of jejunum is better tolerated than the ileum, due to bile salt and vit. B12 absorption capacity of the ileum.
MEDICAL THERAPY: • Management of primary condition causing intestinal resection • Correct fluid & electrolyte imbalance. • TPN, enteral nutrition is gradually introduced. • H2 receptor antagonist --> to reduce gastric acid secretion. • Antimotility agents (loperamideHCL). • Octreotide to reduce volume of gastrointestinal secretion.
SURGICAL THERAPY Goal is to increase nutrient and fluid absorption by slowing intestinal transit or increasing intestinal length • Slow intestinal transit: • Segmental reversal of the small bowel. • Interposition of a segment of colon. • Construction of small intestinal valves. • Electrical pacing of the small bowel. • Intestinal lengthening operation: Serial transverse enteroplasty procedure.
SURGICAL THERAPY Intestinal transplant: Indicated in presence of life threatening complication attributed to intestinal failure or long term TPN therapy.