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Histology 1.4. : Glands

Histology 1.4. : Glands. Gland: a single epithelial cell, or grouping of cells specialized for secretion. Secretion: energy-consuming process by which the cell takes up small molecules and transforms them via intracellular biosynthesis into a more complex product then actively

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Histology 1.4. : Glands

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  1. Histology 1.4. : Glands Gland: a single epithelial cell, or grouping of cells specialized for secretion. Secretion: energy-consuming process by which the cell takes up small molecules and transforms them via intracellular biosynthesis into a more complex product then actively releases it from the cell. The product is utilized by the organism in several ways. Excretion: the organism gets rid of harmful or toxic metabolic end-products or useless waste material.

  2. Classification of glands: I. Based on morphology: unicellular and multicellular Unicellular, intraepithelial gland: goblet cell Intestinal epithelium: simple columnar epithelium (2) goblet cells (1) the arrow shows the nucleus (3) TEM image of the same type of unicellular gland, the goblet cell

  3. CLASSIFICATION OF MULTICELLULAR GLANDS: With ducts: exocrine glands Without ducts: endocrine glands

  4. CLASSIFICATION OF EXOCRINE GLANDS (based on morphology): Simple tubular Coiled tubular Branched tubular Simple acinar Branched acinar Compound tubular Compound acinar Compound tubuloacinar

  5. SOME EXAMPLES: Simple tubular gland: intestinal gland of Lieberkühn Schematic drawing LM microphoto

  6. Coiled tubular gland: sweat glands of the skin Schematic drawing LM microphoto

  7. Branched tubular gland: fundic glands in the stomach Schematic drawing LM microphoto

  8. Fundic gland from the stomach - endpiece

  9. Simple acinar gland: Frog skin: mucous and toxin-producing glands Compact form without lumen: sebaceous gland of mammalian skin

  10. Branched acinar gland:larger sebaceous glands of the skin

  11. Compound tubular gland: esophageal gland duct segment capillary secretory acini capillary lumen

  12. Compound tubuloacinar glands: Mandibular gland Parotid gland

  13. Composition of compound glands: Parenchyma composed of lobes and lobules, ducts The duct system of the compound glands: Acinus Intercalated duct Striated (salivary duct) Interlobular duct Lobar duct Main duct

  14. Model of the gland: a bunch of grapes: berry= acinus stalk of berry: intercalated duct

  15. Intralobular striated (salivary) duct Interlobular duct

  16. II. Type of secretory product: • Serous gland: composed of acini with narrow lumen (1) • secretory cells have round, basally located nuclei (2) • the cytoplasm of the cells is basophilic (3) Pancreas (see the micrograph) and parotid gland are purely serous producing thin watery fluid rich in proteins (mainly enzymes) 3 1 2

  17. 2. Mucous glands: composed of acini with wide lumen secretory cells have flattened nuclei at the base their cytoplasm is very weakly stained Esophageal glands (see the micrograph) are purely mucous producing thick viscous fluid, rich in mucopoly- saccharides for lubrication and protection of internal body surfaces

  18. 3. Seromucous glands: mucous acini surrounded by serous cells forming a demilune shape The submandibular gland of some species (monkey, human, cattle) is seromucous. Red arrows point at mucous cells, blue arrows point at the demilune –shaped group of serous cells (Demilune of Gianuzzi)

  19. Seromucous gland, haematein-eosin staining Seromucous gland, alciane blue staining

  20. III. Modes of secretion: • Merocrine secretion: • The secretory process is an exocytosis • The secretory cell remains completely intact • Most of the glands secrete in a merocrine manner • Exocrine pancreas Submandibular gland

  21. 2. Apocrine secretion: • the secretum is gathered at the apical portion of the cell • the secretum leaves the cell membrane-bounded (pinched off) • the cell remains alive, but a part of it goes with the secretory droplet Examples: sweat and mammary glands

  22. Membrane-bound secretory droplets of a sweat gland

  23. 3. Holocrine secretion: • the secretory cell gradually fills up with secretum • the cell organelles degenerate • the cell dies, its membrane breaks and the secretum empties The sebaceous gland is a holocrine gland. Dead cells are replaced by the mitotic divison of basal cells

  24. Absorptive epithelium: its main function is to absorb. Morphology of these epithelial cells exhibit cuticular border (intestine) or brush border (kidney tubules). Please note: at fine structural level both are microvilli ! EM micrograph of the apical surface with microvilli Intestinal epithelium: the arrow shows the cuticular border

  25. Pigmented epithelium: Epithelial cells contain melamosomes: brown color EM Pigmented epithelium in the eye at LM level shows brown pigmentation. At EM level the melanosomes appear as electron dense bodies in the cytoplasm. LM

  26. Sensory epithelia: Main function is sensation Types: primary, secondary sensory epithelium true nerve cells Primary sensory epithelium: olfactory epithelium

  27. Secondary type of sensory epithelia: Example: sensory cells of the taste buds

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