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Nitric Oxide in Health, Disease, and Therapeutics

Discover the impact of Nitric Oxide (NO) in health & disease, potential therapies, and groundbreaking research at Wake Forest University. Learn how NO enhances cardiovascular function, acts as a vasodilator, inhibits platelet aggregation, and offers anti-inflammatory benefits by reducing reactive oxygen species (ROS). Explore its role in rescuing endothelial dysfunction, treating pulmonary hypertension, and protecting against ischemic reperfusion injury. Uncover how NO deficiency contributes to pathology, especially in hemolytic conditions, and its potential in improving blood transfusion with developed substitutes. Follow current projects on Hemolysis, Hemoglobin Nitrite reactivity, and development of NO-based compounds. Unveil the Nitrite therapy advancements in sickle cell disease and chronic vascular conditions. Dive into the world of Nitrate intake for enhanced physical and cognitive health. Witness the fascinating journey of Nitrite as a performance-enhancing tool for Olympic athletes through beet juice.

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Nitric Oxide in Health, Disease, and Therapeutics

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  1. N O Nitric Oxide in Health, Disease, and Therapeutics Daniel Kim-Shapiro Department of Physics and Translational Science Center

  2. NO deficiency contributes to much pathology and it can be used to treat many diseases • NO improves cardiovascular function • Vasodilator • Inhibits platelet aggregation • Anti-inflammatory (reduce ROS) • Rescue endothelial dysfunction (aging) • Treatment for pulmonary hypertension • Protective against ischemic reperfusion injury • Deficient in hemolytic conditions (incl stored blood) Wake Forest University

  3. Discovery that Nitrite Vasodilates Cosby et al, Nature Med., 2003 Wake Forest University

  4. Nitrite Therapeutics Sickle Cell Disease Chronic vascular disease

  5. Nitrite Therapy via Nitrate Intake

  6. Nitrate Diet and Physical/Cognitive Functional Health This is your brain Low High This is your brain on nitrite Wake Forest University

  7. “Have you heard about beet juice? The blood-red elixir of the beet is apparently the hottest thing for Olympic athletes looking for a non-illegal performance boost. Soon the world will be caught up in beet juice fever. Too bad it tastes like "sweet dirt.“”

  8. Current Projects Hemolysis: NO, platelets and ROS Further Studies in Hemoglobin Nitrite reactivity Develop compounds to treat Hemolysis Study nitrite in older adults and disease Improve blood transfusion and develop blood substitutes Wake Forest University

  9. Tools Quantum Gravitational Fragility Tester 3000

  10. Kim-Shapiro Lab and Associates Wake Forest University

  11. Funding Wake Forest University

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