1 / 6

Widely Found and Studied Neurotransmitters

Widely Found and Studied Neurotransmitters. Glutamate – has excitatory functions 4 Ascending activating systems are very important Cholinergic System uses acetylcholine Adrenergic system uses noradrenalin Dopaminergic system (actually 2 systems) use dopamine

fleta
Download Presentation

Widely Found and Studied Neurotransmitters

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Widely Found and Studied Neurotransmitters • Glutamate – has excitatory functions • 4 Ascending activating systems are very important • Cholinergic System uses acetylcholine • Adrenergic system uses noradrenalin • Dopaminergic system (actually 2 systems) use dopamine • Serotonergic system uses 5-Ht or serotonin • GABA or gamma-amino butyric acid – has inhibitory functions

  2. Acetylcholine • Activate two types of receptors: • Nicotinic receptors– also stimulated by nicotine and inactivated or blocked by curare • Muscarinic receptors– stimulated by muscurine and blocked by atropine and scopolamine – use second messenger

  3. Monoamines • Dopamine – up to 6 types of receptors • Tyrosine forms L-dopa • L-dopa synthesized to form dopamine • Norepinephrine – created by synthesis of dopamine • Epinephrine – created from Norepinephrine • Serotonin (5-Ht) – synthesized from tryptophan

  4. Peptides • Many types of neuropeptides; two have been extensively studied • Sustance P – constriction and dilation of blood vessels • Opioid types – • Endorphins • enkephalins

  5. How Drugs Work in the Brain • They work at the level of the synapse • Agonists • Antagonists

  6. Possible Drug Actions at the Synapse • increase or decrease the synthesis or production of neurotransmitters • increase or decrease the ability of the cell to store the chemical in vesicles • increase or decrease the amount of transmitter released by vesicles into the synapse • it can increase the number and length of time a receptor is open by increasing or decreasing the production of enzymes that break down the neurotransmitter • block or enhance the reuptake and reuse of the neurotransmitter • Altering the actions of second messegers

More Related