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Bio Balance Corporation

Bio Balance Corporation. Improving Medications Using Cost-Effective Processes. Building a Broad and Flexible Technology. Enhancing the safety and efficacy of existing pharmaceuticals & Creating new pharmaceuticals. G Protein-Coupled Receptors (GPCRs).

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Bio Balance Corporation

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  1. Bio Balance Corporation Improving Medications Using Cost-Effective Processes

  2. Building a Broad and Flexible Technology Enhancing the safety and efficacy of existing pharmaceuticals & Creating new pharmaceuticals

  3. G Protein-Coupled Receptors(GPCRs) • It is conservatively estimated that 30-50% of all pharmaceuticals interact with GPCRs. • These receptors are widely distributed within our bodies and are integral to our senses, thoughts and sensations. • They all desensitize to continued stimulation by agonists.

  4. Gsa – Heart, brain,lung, neurons, kidney, liver, adrenal gland Gia – Brain, olfactory, heart, all tissues Activate Ca2+ channels, cardiac positive inotropy, contractile proteins Regulate K+, Ca2+ channels, inhibit cAMP and Ca/CaM actions Some Common GPCRs -Their Distribution and Effector Systems Distribution: Effects:

  5. The Problem of Desensitization

  6. Desensitization Fade Autoinhibition Tachyphylaxis Tolerance Down-regulation Resistance Terminology

  7. The History of Desensitization

  8. Interesting and Historical Points: 1957 – First detailed experimental observations of receptor desensitization by del Castillo & Katz Proc.Roy. Soc. Lond. 146, 369-381. 1972 – From search - one paper titled “receptor desensitization by lobeline and nicotine” 1988 – The Rose patent # 5,316,759 (May 31, 1994) refers to work dating back to 1988 on the agonist-antagonist combination of nicotine with mecamylamine. 1991 – Geoffroy, et al. “Reduction of Desensitization of a Glutamate Ionotropic Receptor by Antagonists” Molecular Pharmacology 39, 587-591.

  9. Patents Combining Agonists with Antagonists

  10. Scientific Objective:Preventing Desensitization

  11. Methodology Medication (“agonist” – e.g., isoproterenol, morphine) + Antagonist to prevent desensitization (“antagonist” – e.g., metoprolol, naloxone) = New & Improved Medication

  12. The Heart of Bio Balance’s Technology The determination of the optimal ratio of agonist and antagonist by our patented method. This method is based upon a biophysical model for the receptor response. This allows Bio Balance to create patentable compositions using the “best mode” of practice.

  13. A Representation of the two-state model showing 5-HT binding

  14. Experimental vs. Theoretical curves for various receptor responses

  15. Applications of Bio Balance’s Technology • Extend the patent protection of existing drugs • Create new drugs as combinations of generic drugs • Assist in drug development by salvaging previously discarded drug candidates because of excessive desensitization or fade

  16. Advantages of Bio Balance’s Technology • Better control of the therapeutic response. • Cheaper to develop • Multiple therapeutic areas can be targeted • Can combine generic drugs • Potentially quick acceptance by physicians as a technically superior design of previously accepted drugs. • Multiple new drugs can be created as compositions within several therapeutic areas such as cardiovascular, pain, pulmonary, brain/memory, tocolytic, etc.

  17. Bio Balance’sTherapeutic Targets Heart Asthma Pain Memory Other GPCRs Premature Labor

  18. Conclusion Bio Balance has a broad and flexible technology to enhance existing pharmaceuticals and to create new pharmaceuticals that work better with fewer side-effects.

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