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Microbial Risk Assessment for Benefit Estimation of Antimicrobial Consumer Handproducts

Microbial Risk Assessment for Benefit Estimation of Antimicrobial Consumer Handproducts. Charles N. Haas Drexel University. Acknowledgment Mark Weir, Graduate Assistant. Qualifications & Disclaimer. 20+ years of experience developing & applying microbial risk assessment

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Microbial Risk Assessment for Benefit Estimation of Antimicrobial Consumer Handproducts

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  1. Microbial Risk Assessment for Benefit Estimation of Antimicrobial Consumer Handproducts Charles N. Haas Drexel University Acknowledgment Mark Weir, Graduate Assistant

  2. Qualifications & Disclaimer • 20+ years of experience developing & applying microbial risk assessment • Fellow, American Academy of Microbiology, Society for Risk Analysis, American Association for the Advancement of Sciences • Work on antimicrobial hand products supported by SDA/CTFA

  3. Conclusions • Microbial risk assessment can be used to quantify the benefits of use of antimicrobial-containing consumer hand products • For the scenario considered, use of such products resulted in reduction in median risk from a single exposure by a factor of 3 to a factor of 16 (depending on active ingredient)

  4. Methods • Health Care Personnel Hand Wash study data on various formulations of product with different organism strains • Analyzed reduction (log N/N0) to get distributions • Performed Monte Carlo analyses in a defined scenario according to Haas et al. (Int. J. Hyg. Env. Hlth, in press)

  5. Sources of Data • SDA/CTFA contractor compiled data from company records • ASTM E11-74 from a single contract laboratory • Summarized inactivation ratios transmitted to us for analysis

  6. Studies in Current Data Set (*) information available from prior studies

  7. Scenario Considered • Handling ground beef containing E. coli • Beef --> hands • From ground beef prevalence and transfer studies • Hand decontamination by washing • From current data • Transference from hand to mouth • From transference studies • Dose-response from ingested E. coli • Previously assessed from human feeding trials

  8. Single Event Risk Reduction - Summary

  9. Conclusions Restated • Microbial risk assessment can be used to quantify the benefits of use of antimicrobial-containing consumer hand products • For the scenario considered, use of such products resulted in reduction in median risk from a single exposure by a factor of 3 to a factor of 16 (depending on active ingredient)

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