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Cardiovascular Disease (CVD). A general term for disease s of the heart and/or blood __________ _____% of all deaths annually 2,600 American deaths each day Average of 1 death every 33 seconds. Atherosclerosis (a type of CVD).
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Cardiovascular Disease (CVD) A general term for diseases of the heart and/or blood __________ • _____% of all deaths annually • 2,600 American deaths each day • Average of 1 death every 33 seconds
Atherosclerosis (a type of CVD) The progressive narrowing and hardening of an artery due to build up of plaque.
Pathological Determinants of Atherosclerosis in Youth • 2,876 subjects aged 15-34 • 100% had intimal lesions in aorta • Subjects aged 15-19: 60% had coronary artery lesions • Subjects aged 30-34: 70% of females and 80+% of males had coronary artery lesions JAMA 281:727, 1999
Pathological Determinants of Atherosclerosis in Youth Key Conclusions: • Atherosclerosis begins in youth • Fatty streaks & clinically raised lesions increased rapidly in prevalence and extent during ages 15 to 34 • The earlier the cardiovascular risk factors are modified the greater the potential for deferring the onset of heart disease • Primary prevention of atherosclerosis must begin in childhood or adolescence
Coronary Artery Disease – Atherosclerosis of coronary arteries
Non-Controllable Risk Factors of Coronary Artery Disease • _________ • _________ • Being male. 1. 2.
Major Controllable Risk Factors for Coronary Heart Disease • Tobacco use/Smoke • High Blood Cholesterol • High Blood Pressure • Physical Inactivity • _________________ • ___________
Other Recognized Risk Factors • High blood homocysteine level • High blood iron level (males) • Low flavonoid intake • Inflammation
Tobacco Use/Smoke • Damages inner lining of artery • Stimulates platelets to clot • Produces free radicals • Decreases HDL levels • Constricts vessels • Reduces oxygen carrying capacity • Increases heart rate
Blood Cholesterol - Risk LipidDesirableBorderlineHigh Total <200 200-239 240+ LDL <100 130-159 160+ HDL >60 41-50 <40 Trig. <150 150-199 200+ • Excessive LDL or inadequate HDL leads to deposition of cholesterol in artery
Blood Pressure Rating ClassificationSystolicDiastolic Optimal <120 <80 _______________ 120-139 80-89 Hypertension 140+ 90+ • Damages inner lining of artery • Causes arteries to become rigid
Blood Pressure • Systolic pressure: the pressure exerted against the walls of the artery during heart _______________ • Diastolic pressure: the pressure exerted against the walls of the artery during the _______________ phase
Physical Inactivity • Lower HDL levels • Lack of stimulus for collateral circulation • Lack of stimulus for endothelial function • Loss of vessel elasticity • Inhibited glucose metabolism • No stimulus for myocardium strengthening • Increased risk for high blood pressure
Obesity & Overweight • Increased risk for high cholesterol levels • Increased risk for elevated blood pressure • Increased risk for type II diabetes
Diabetes • Damages inner lining of artery • Modification of LDL cholesterol