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“Sapienza” University of Rome Department of Ophthalmology Ocular Immunovirology Service

Correlation between visual acuity and inner segment/outer segment junction and cone outer segment tips line integrity in uveitic macular edema. M. La Cava, P. Tortorella, E. D’Ambrosio, F. De Marco, E. Santoro, L. Iannetti. “Sapienza” University of Rome Department of Ophthalmology

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“Sapienza” University of Rome Department of Ophthalmology Ocular Immunovirology Service

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  1. Correlation between visual acuity and inner segment/outer segment junction and cone outer segment tips line integrity in uveitic macular edema M. La Cava, P. Tortorella, E. D’Ambrosio, F. De Marco, E. Santoro, L. Iannetti “Sapienza” UniversityofRome DepartmentofOphthalmology Ocular Immunovirology Service

  2. INTRODUCTION • Optical Coherence Tomography (OCT) findings were used to describe the three different morphologic patterns of macular edema (ME): • Diffuse macular edema (DME). • Cystoid macular edema (CME). • - Serous retinal detachment (SRD). DME Increased macular thickness, small low-reflective areas with spongy appearance of the retinal layers. CME Low-reflective intraretinal spaces, clearly defined and separated by thin, high-reflective retinal tissue. SRD Neuroretinal layer separation from the retinal pigment epithelium (RPE).

  3. On spectral-domain Optical Coherence Tomography (SD-OCT), the outer retina has four distinct hyperreflective lines: 1. external limiting membrane (ELM). 2. inner segments and outer segments of the photoreceptors junction (IS/OS). 3. the cone outer segment tips (COST) or Intermediate Line or Verhoeff’s membrane. 4. RPE. 1. The innermost ELM is formed by the back reflection of the zonulaeadherentes that join the inner segment to the Muller cells. 2. The IS/OS junction is thought to represent the boundary between the inner and outer segments of the photoreceptors and is localized between the ELM and the RPE histologically. 3. The COST line represents the outer tip of the cones. 4. The outermost RPE line separates the photoreceptors from the Bruch’s membrane and choriocapillaris. PURPOSE To investigate the correlation between best-corrected visual acuity (BCVA)  and fovealIS/OS junction and the COST line integrity in eyes with uveitic ME.

  4. METHODS • 52 eyes of 33 patients. • Retrospective, observational study. • All patients underwent  SD-OCT examination with SpectralisOCT (Heidelberg Engineering, Heidelberg, • Germany). • The correlation between the BCVA and ME pattern, the integrity of the foveal • IS/OS junction and COST line was evaluated with a multivariate correlation. • The correlation between the interruption of the foveal IS/OS junction and COST line was • analyzed with a univariate logistic correlation. Demographic and clinical characteristics of the study population

  5. RESULTS Number of patient, mean foveal thickness (CST) and median BCVA according to the different morphological features observed. Negative correlation between BCVA and central retinal thickness (p<0.001), cystoid pattern of edema (p<0.05) and COST line interruption (p<0.01). Strong correlation between IS/OS segment and COST line integrity (p<0.05). a. Disruption of COST line. b. Disruption of the photoreceptor IS/OS junction. c. Disruption of COST line and IS/OS junction together.

  6. CONCLUSIONS • IS/OS segment defect and COST line interruption and central retinal thickness are correlated with poor vision. • BCVA is strongly affected by the cystoid pattern. • The COST line integrity appears to be the most important factor in the visual prognosis of uveitic ME. FINANCIAL DISCLOSURE: This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

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