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Artificial Skin: New Opportunity for Treatment of Burn Victims

Artificial Skin: New Opportunity for Treatment of Burn Victims. By Michelle Brubacher MEEN 3344 Spring ‘06. Beginning. Yannas and Bruke “Pioneers of Artificial Skin” Complex of collagen and condroiton sulphuric acid with silicon membrane. How it Works.

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Artificial Skin: New Opportunity for Treatment of Burn Victims

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  1. Artificial Skin: New Opportunity for Treatment of Burn Victims By Michelle Brubacher MEEN 3344 Spring ‘06

  2. Beginning • Yannas and Bruke “Pioneers of Artificial Skin” • Complex of collagen and condroiton sulphuric acid with silicon membrane

  3. How it Works • Artificial skin is secured over wound during surgery • The skin remains in place for several weeks and allows new tissue to grow in to bottom matrix layer • Top layer provides protection from infection and dehydration

  4. Benefits • Protect skin from infection • Keep in moisture to prevent dehydration • Encourage healing through construction of new tissue by infiltration of epidermal cells and fibroblasts • Allow for less severe scarring • More readily available

  5. Improvements • Biodegradable skin • Doesn’t need to be removed • Slowly releasing antibiotic • Prevents infection • Re freeze dried artificial skin • Easier storage and reconstitution • Addition of epithelial growth factor and basic fibroblast growth factor • Increased regeneration of tissue

  6. References • Katsuya Kawai, Shegehiko Suzuki, Yasuhiko Tabata, Yoshito Ikada, and Yoshihiko Nishimura. “Accelerated Tissue Regeneration Through Incorporation of Basic Fibroblast Growth Factor-Impregnated Gelatin Micro spheres into Artificial Dermis.” Science Direct. January 24, 2000. • Shigehiko Suzuki, Kazuya Matsuda, Nobuhiko Isshiki, Yashushi Tamada and Yoshito Ikada. “Experimental Study of Newly Developed Bi-layer Artificial Skin.” Biomaterials 1990, Vol. 11: July. • Kazuya Matsuda, Shegehiko, Suzuki, Nobuhiko Isshiki, Kazuo Yoshioka, Ryoichi Wada, S.H. Hyon, and Yoshito Ikada. “Evaluation of a Bi-layer Artificial Skin Capable of Sustained Release of an Antibiotic.” Science Direct. December 20, 1990. • Kazuya Matsuda, Shigehiko Suzuki, Nobuhiko Isshiki and Yoshito Ikada. “Re-freeze Dried Bi-layer Artificial Skin.” Science Direct. April 30, 1993. • Sung Ran Hong, Seung Jun Lee, Jong Won Shim, Young Seon Choi, Young Moo Lee, Kand Won Song, Moon Hysang Park, Young Soo Nam and Sang In Lee. “Study on Gelatin-containing Artificial Skin IV: A Comparative Study on the Effect of Antibiotic and EGF on Cell Proliferation During Epidermal Healing.” Biomaterials 2001, Vol. 22: October. • Risako Matsui, Naganari Okura, Ken-ichi Osaki, Jun Konishi, Kazuhito Ikegami, and Mikio Koide. “Histological Evaluation of Skin Reconstruction Using Artificial Dermis.” Biomaterials 1996, Vol. 17

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