1 / 9

BEH Ç ET’S DISEASE

BEH Ç ET’S DISEASE. Idiopathic multisystem disease More common in men Occurs in 3 rd - 4 th decade Highest incidence in Mediterranean region and Japan Associated with HLA-B5. BEH Ç ET’S DISEASE Aetiology. Unknown Various bacteria and viruses suggested

fynn
Download Presentation

BEH Ç ET’S DISEASE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. BEHÇET’S DISEASE • Idiopathic multisystem disease • More common in men • Occurs in 3rd - 4th decade • Highest incidence in Mediterranean region and Japan • Associated with HLA-B5

  2. BEHÇET’S DISEASEAetiology • Unknown • Various bacteria and viruses suggested • No good evidence to suggest any of them • Perpetuated by autoimmune response and CD4 + T-cells • Tumour necrosis factor (TNF) thought to be important

  3. BEHÇET’S DISEASE Systemic Involvement (1) Oral aphthous ulceration – 100%

  4. BEHÇET’S DISEASE Systemic Involvement (2) Genital ulceration – 90%

  5. BEHÇET’S DISEASE Systemic Involvement (3) • Skin lesions – 80% • Erythema Nodosum • Acneiform • Uveitis 70% (inflam. of iris, ciliary body or choroid)

  6. BEHÇET’S DISEASE Systemic Involvement (4) • CNS involvement – strokes, fits • Major vessels eg superior Vena cava obstruction • Increased skin response to trauma eg blood taking

  7. BEHÇET’S DISEASEOcular Features (1) • Acute iritis • Pain, redness & VA • Flare (PTN exudation) • Inflammatory cells in anterior chamber • KPs (Inflammatory cells at posterior surface of cornea) • Recurrent hypopyon (Fluid level of WBC) The red or white eye

  8. BEHÇET’S DISEASEOcular Features (3) • Marked inflammation of the eye • Retinal vasculitis and haemorrhage (inflam. of retinal vessels) • Occlusive periphlebitis (venous sheathing & occlusion) • Retinal microinfarcts • Very damaging to vision: retinal damage and optic nerve atrophy • Cataract or glaucoma

  9. BEHÇET’S DISEASETreatment • Systemic Steroids • Systemic immunosuppressive agents • Interferon-alpha may have immunodulating effects • Anti-TNF monoclonal antibodies may be of help

More Related