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A Biology and Engineering Cooperative Project

A Biology and Engineering Cooperative Project. James W. Stevens M. Karen Newell University of Colorado at Colorado Springs 30 April 2005. general background. connection between cellular metabolic pathways and immune system response surface signals tied to mitochondrial activity and fuel.

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A Biology and Engineering Cooperative Project

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  1. A Biology and Engineering Cooperative Project James W. Stevens M. Karen Newell University of Colorado at Colorado Springs 30 April 2005

  2. general background • connection between cellular metabolic pathways and immune system response • surface signals tied to mitochondrial activity and fuel

  3. biology science driver cell cultures growing conditions cell counting and physical preparation engineering data acquisition temperature measurements data reduction data smoothing cooperative effort

  4. background-this project • 2 mouse leukemia lines L1210 – not drug resistant L1210/ddp– drug resistant • cultured to 10^6 to 10^8 cells • stressed with bleach • measurable, repeatable differences • different culture conditions, metabolic states

  5. data analysis first law of thermodynamics:

  6. 1 0.5 0 0 0.2 0.4 0.6 0.8 1

  7. data smoothing least square curve fit: minimize

  8. summary • leverage complementary capacities– specific to people and project • involve students • plunge into a new area

  9. other cooperative efforts at UCCS • biomechanics –biology, mechanical engineering • orthopedic mechanics –MERIC, biology, mechanical engineering • feedback controls –MAE, biology • microgravity – MAE • assistive technologies – MATH, biology

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