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CE TAG

What are the main classes of lipids? Where are they found in the cell? Where did they come from?. LIPIDS hydrophobic or amphipathic small molecules. R ough endoplasmic reticulum (ER ). ribosome. mitochondrion. cell membrane. cytoplasm cytosol. lysosome. peroxisome. peroxisome.

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CE TAG

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  1. What are the main classes of lipids? Where are they found in the cell? Where did they come from? LIPIDS hydrophobic or amphipathic small molecules Rough endoplasmic reticulum (ER) ribosome mitochondrion cell membrane cytoplasm cytosol lysosome peroxisome peroxisome nucleus smooth endoplasmic reticulum free ribosome Golgi complex lipid droplet monolayer PL, C CE TAG • Fatty acids • Free (toxic unless esterified) • Esterifed in glycerophospholipids,sphingolipids, glycerol lipids and sterol lipids Lipids Classes

  2. What are the main classes of lipids? Where are they found in the cell? Where did they come from? LIPIDS hydrophobic or amphipathic small molecules Rough endoplasmic reticulum (ER) ribosome mitochondrion cell membrane cytoplasm cytosol lysosome peroxisome peroxisome nucleus smooth endoplasmic reticulum free ribosome Golgi complex peroxisome lipid droplet In cell membrane and lipid droplets CE TAG In membranes In lipid droplets • Fatty acids • Free (toxic unless esterified) • Esterifed in glycerophospholipids,sphingolipids, glycerol lipids and sterol lipids Lipids Classes

  3. What are the main classes of lipids ? Where are they found in the cell? Where did they come from? Import /Exportand Synthesis/Trafficking LIPIDS ribosome Rough endo. reticulum mitochondrion cell membrane cytoplasm cytosol lysosome nucleus CE GL CE GL • import • CirculatingLipoprotein • LDL from liver • Chylomicronsfrom intestines not to scale C, GP FA peroxisome peroxisome smooth endoplasmic reticulum free ribosome Golgi complex lipoprotein peroxisome lipoprotein FA not to scale lipid droplet FA Exported FAfrom fat cells (adipocyte)bind to serum albuminfor transport to tissue Circulating FA (grey spacefill) importedfrom adipoctyes bound to protein: serum albumin; FA to mitochondria foroxidation/ATP prod. lipoprotein not to scale • Circulating Lipoprotein • VLDL exported from liver (synthesized) lipids • Chylomicrons exported from intestines (ingested lipids) IMPORT/EXPORT

  4. What are the main classes of lipids? Where are they found in the cell? Where did they come from? Importand Synthesis/Trafficking LIPIDS synthesized in cytoplasm Mostly in liver, mammary tissue Rough endo. reticulum ribosome mitochondrion cell membrane cytoplasm cytosol elongation lysosome elongation, desaturation elongation FA FA FA FA GL SP2 SP2 SP PM GP1 GP PM GL PM GP ST CE C C GP C ST GP1 peroxisome Golgi: sorts lipids ER (smooth)main site oflipid synthesis smooth endoplasmic reticulum Golgi complex lipid droplet Cardiolipin and phosphatidyl glycerol (2 lipids also found in bacteria, are made in the mitochondrion Ceramide, a precursor of SP, is made in mitochondria.

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