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Ulrik Gerdes Klinisk Biokemisk Laboratorium ∙ Center for Psykiatrisk Grundforskning ∙ Risskov

How to examine the effects of preanalytical factors? XXX Nordic Congress in Clinical Biochemistry  Copenhagen  15-06-06. Ulrik Gerdes Klinisk Biokemisk Laboratorium ∙ Center for Psykiatrisk Grundforskning ∙ Risskov. Suggestions (I).

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Ulrik Gerdes Klinisk Biokemisk Laboratorium ∙ Center for Psykiatrisk Grundforskning ∙ Risskov

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  1. How to examine the effects of preanalytical factors?XXX Nordic Congress in Clinical Biochemistry  Copenhagen 15-06-06 Ulrik GerdesKlinisk Biokemisk Laboratorium ∙ Center for Psykiatrisk Grundforskning ∙ Risskov

  2. Suggestions (I) • Think of the task as a comparison of methods, and use statistical models that are developed for that purpose • Always include a procedure (method) that is either considered ‘state of the art’ and/or is your standard procedure • Design the study so that you can both examine the effects on bias (systematic differences) and variation • Eliminate (or minimize) irrelevant sources of variation • Increase the size of the study to increase the precision of the estimates of the effects • Study the effects over a range of measurement values for the biochemical variables in question

  3. Suggestions (II) • Don’t use aggregated statistical test (i.e. p-values) to evaluate whether two procedures are comparable • Compare the observed differences with the quality goals you have set for the analytical method • Share your results with others!

  4. Summary Use plenty! Randomize! Procedure A Patient/Sample Analysis Procedure B Use dublicates or triplicates! Evaluation Data analysis What are the effects compared to the quality goals for the analysis? Use a proper model!

  5. Thank you for your attention!

  6. Questions?

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