1 / 11

A Literature Critique of the Nature article published April 2002

Decreased susceptibility to NMU-induced mammary carcinogenesis in transgenic rats carrying multiple copies of a rat  ras  gene driven by the rat Harvey  ras  promoter. A Literature Critique of the Nature article published April 2002. Introduction.

gala
Download Presentation

A Literature Critique of the Nature article published April 2002

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Decreased susceptibility to NMU-induced mammary carcinogenesis in transgenic rats carrying multiple copies of a rat ras gene driven by the rat Harvey ras promoter A Literature Critique of the Nature article published April 2002

  2. Introduction • There were 6 authors for this paper, with the primary author Todd A Thompson2. The others were Jill D Haag1, Mary J Lindstrom3, Anne E Griep4, Jan K Lohse4 and Michael N Gould1,2 • Generally the scientists were considering how the body reacts when there is an over expression of Ras protein, and what this reaction implies for mammary carcinogenesis (breast cancer). • According to the authors, Ras has the potential to function as a modifier gene in repressing mammary carcinogenesis.

  3. Overview • Literary analysis (i.e. Analyzing the writing style of the authors) • The correct way to format a Journal-Style Scientific Paper • Breakdown from the Abstract to the Conclusion • Impact factor of the article • vs impact factor of the journal

  4. Literary Analysis HOW ON EARTH? • What is the correct way to format a journal style paper? • Title • Authors and Affiliation • Abstract • Introduction • Methods • Results • Discussion • Acknowledgments and Literature Cited • How did the authors of this paper do it? • Mixed it up • Title • Authors and Affiliation • Abstract • Introduction • Results • Discussion • Methods • Acknowledgments and References

  5. Literary Analysis: Breakdown The Purpose Methods/ Experimental Design • Abstract: The function of an abstract is to summarize in one paragraph the major aspects of the entire paper. It should include • The purpose of the paper • The experimental design and methods used • The major findings • A brief summary of their conclusions. • Did they get it right?

  6. Literary Analysis: Breakdown Results Conclusion • Abstract: The function of an abstract is to summarize in one paragraph the major aspects of the entire paper. It should include • The purpose of the paper • The experimental design and methods used • The major findings • A brief summary of their conclusions. • Did they get it right?

  7. Literary Analysis: Breakdown • Introduction • Methods: • One line under statistical analysis “The effect of transgene on 18-week tumor multiplicity was assessed for the HrHr and HrKr transgenic lines using a generalized linear model assuming Poisson distributed counts.” • Results: • Seven different instances of “data not shown” is not commendable. Show more data instead.

  8. Literary Analysis: Breakdown • Results • Appropriate use of tables and diagrams • Indicating “p-value” which shows the significance of the data they got • Showing relationships using graphs and clearly labeled pictures Figure 1 from the article Figure 5 from the article, Assays Table 1 from the article

  9. Literary Analysis: Breakdown • Since the format of the paper was a little different, the article ended with the Materials and Methods section • Cliff hanger feeling • Instead, they should have ended with the Discussion section • In conclusion, it was a decent research article – B plus

  10. Impact Factor • The article had been cited only twice on PubMed • However, the scientific journal Nature is a very high impact journal • So the article has actually been cited at least 46 times over the last 11 years making it a relatively high impact document June 2012 Copy of Nature

  11. Questions?

More Related