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Reproducibility of results in published literature

ITN TrialShare: Promoting reproducible research and transparency in clinical trials Adam Asare, PhD Director, Data Analysis 12/11/2012. Reproducibility of results in published literature.

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Reproducibility of results in published literature

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  1. ITN TrialShare: Promoting reproducible research and transparency in clinical trialsAdam Asare, PhDDirector, Data Analysis 12/11/2012

  2. Reproducibility of results in published literature Ionnidis, P. et al. Repeatability of published microarray gene expression analyses. Nat Gen , 41:2, Feb 2009

  3. Immune Tolerance Network(ITN) • Clinical trials consortium whose mission is to accelerate the development of immune tolerance therapies • Therapeutic areas include: allergy/asthma, transplantation, and autoimmune diseases • Over 50 Phase I/II clinical trials • NIH/NIAID funded for over 12 years, ~30M/year • Numerous academic and industry partners • Core objectives: Innovation & Collaboration • Develop novel assay technologies • Support rigorous and reproducible research • Adhere to standardized platforms and processes • Use best practices approach to statistical methodology • Disseminate data and results to research community

  4. Web access to data and analyses: itntrialshare.org

  5. Data analysis study archive

  6. Manuscript figures and analysis code console Original Analysis Data User-defined analysis figure and output Code Download data and code base Re-run analysis within system

  7. Create a new paradigm for research publishing • Generate high-profile manuscripts that are interactive at the data and code level • Query for information regarding how the published data was generated • Allow exploration of alternative analysis approaches • Benefits realized • Allows rapid review of data and analysis approaches by study team internally for manuscript development • Public resource available to the research community for reference datasets and analysis approaches • Expect additional functionality to be phased in over time

  8. Funding Attribution Slide: General ITN FUNDED BY: National Institute of Allergy & Infectious Diseases FoodAllergy Initiative National Institute of Diabetes & Digestive & Kidney Diseases

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