Herbal Remedy vs. Prescription Drug for Depression - Research Findings

Dec 26, 2024

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Discover the effectiveness of St. John's Wort vs. Paroxetine in treating moderate to severe depression through a randomized controlled double-blind trial. Explore the historical use of St. John's Wort and its popularity as a natural antidepressant in Germany.

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Herbal Remedy vs. Prescription Drug for Depression - Research Findings

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Effective use of the Historical Control Trial

What is an historically controlled trial?. Study participants are treated with the new (test) agentOutcome compared to outcomes from individuals who do not (or have not) received the test agentUnlike a randomized controlled trial RCT:All study participants receive the test agent.Control group is external to the trial.

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Phambili/HVTN 503 Interim Efficacy Analysis A multicenter double-blind randomized placebo-controlled Phase IIB test-of-concept study to evaluate the safety and efficacy of a 3-dose regimen of the Clade B-based Merck Adenovirus serotype 5

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Rectal Microbicides: The Basics Date, Location Your Name

Rectal Microbicides: The Basics Date, Location Your Name. This presentation. Overview of epidemic and prevention Who is IRMA? What is a microbicide? What is a rectal microbicide? Research and advocacy Get involved!. Global HIV/AIDS Picture. 33.2 million people living with HIV/AIDS

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Management of Vitamin D Deficiency and Osteoporosis in Clinical Practice

Management of Vitamin D Deficiency and Osteoporosis in Clinical Practice. M. Ali Karamat MBBS MRCP MD FRCP Consultant Physician and Honorary Senior Lecturer. PTH. Ca 2+ reabsorption & 1,25 DHD. bone resorption Ca 2+ availability. Ca 2+ absorption.

875 views • 34 slides

Randomized Controlled Trials

. ObjectivesAt the completion of module 4, residents should be able to:Describe the design of a Randomized Controlled Trial.Describe the importance of randomization and a control group in the RCT designDefine blinding and list four levels at which studies are blinded.Define an "Intention to Tre

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DOUBLE BLIND DOUBLE DUMMY PLACEBO CONTROLLED RANDOMIZED CLINCAL TRIAL OF IMPLANTABLE NALTREXONE (PRODETOXONE) FOR HEROIN

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A Phase 1 Randomized, Double-Blind , Placebo-Controlled Rectal Safety and Acceptability Study of Tenofovir 1% Gel

MTN-007. A Phase 1 Randomized, Double-Blind , Placebo-Controlled Rectal Safety and Acceptability Study of Tenofovir 1% Gel.

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Folate Augmentation of Treatment – Evaluation for Depression: a randomised controlled trial

Folate Augmentation of Treatment – Evaluation for Depression: a randomised controlled trial . NWORTH open day, May 2012 Yvonne Sylvestre & Richard Tranter. HTA Project 04/35/08 ISRCTN37558856. Background . Depression

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Evidence Based Medicine: Review of the basics

Evidence Based Medicine: Review of the basics. Deb Bynum, MD August 2010. Moving beyond sensitivity and specificity. Hierarchy of Strength of Evidence. N of 1 randomized controlled trial Systematic reviews of randomized controlled trials Single randomized trial

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Evaluating Results

Evaluating Results. The Best Evidence. So far, we’ve learned that a good experiment or clinical trial is: Randomized Double-blind Controlled This is often abbreviated ‘RCT’: Randomized Controlled Trial. Randomization.

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A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine for the prevention of tran

A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine for the prevention of transfusion reactions. Background. Study done in North Carolina with bedside leukoreduction Rates of febrile reactions: RBC transfusions: 0.3-6%

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Tricoci P, N Engl J Med 2012 Farb A, Circulation 2003

Safety and Tolerability of CSL112 in Patients with Stable Atherothrombotic Disease: Results from a Phase 2a, Multicenter, Randomized, Double-Blind , Placebo-Controlled , Ascending-Dose Study .

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EXPERIMENTAL STUDIES

EXPERIMENTAL STUDIES. FRAMEWORK :. Introduction Types of experimental studies Randomized control trial Types of randomized controlled trial (RCT) Phases of clinical trial Design and conduct of an RCT General plan and protocol of an RCT Study population Randomization Blinding

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1. Baselga et al . N Engl J Med 2011

A Phase III, Randomized, Double-Blind, Placebo-Controlled Registration Trial to Evaluate the Efficacy and Safety of Placebo + Trastuzumab + Docetaxel vs. Pertuzumab + Trastuzumab + Docetaxel in Patients with Previously Untreated HER2-Positive Metastatic Breast Cancer (CLEOPATRA).

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Rastelli A et al. SABCS 2009;Abstract 803.

A Double-Blind, Randomized, Placebo-Controlled Trial of High-Dose Vitamin D Therapy on Musculoskeletal Pain and Bone Mineral Density in Anastrozole-Treated Breast Cancer Patients with Marginal Vitamin D Status. Rastelli A et al. SABCS 2009;Abstract 803. Introduction.

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C.R.E.D.O. C lopidogrel for the R eduction of E vents D uring O bservation

C.R.E.D.O. C lopidogrel for the R eduction of E vents D uring O bservation. Multicenter Multinational (USA, Canada) Prospective Randomized Double Blind Placebo Controlled Trial. From Steinhubl et al, JAMA 2002;228:2411-20. C.R.E.D.O. Aim of the Study.

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Authors: Lee S-M et al. Reviewers: Dr. C. Butts, Dr. R. Burkes Date posted: Sept 20, 2007

A phase III, randomized, double-blind, placebo controlled trial of etoposide/carboplatin with or without thalidomide in advanced small cell lung cancer. Authors: Lee S-M et al. Reviewers: Dr. C. Butts, Dr. R. Burkes Date posted: Sept 20, 2007. Background.

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INTRODUCTION

A randomized controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome.

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Yazdanfar A. et al. Dermatol Surg 2008; 34: 656-659

Treatment of common warts with an intralesional Mixture of 5-Fluorouracil, Lidocaine, and Epinephrine: A prospective Placebo-controlled, Double-Blind Randomized Trial. Yazdanfar A. et al. Dermatol Surg 2008; 34: 656-659. Introduction.

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Human Trials

Human Trials “Gold standard”: Controlled, double-blind ; versus greater potential of whole food diet Vitamins/minerals/etc. for learning and behavior (Controlled, double-blind, successful, but needs follow-up with whole diet)

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Blinded patient population

+. Blinded patient population. -. Controlled, Randomized, Double-Blind, Multicenter, Prospective, Phase III Clinical Trial with Single Crossover. Experimental variable (CPE). Experimental variable (CPE). Recruit patients: 67 at MDACC, 33 at TSRCC.

91 views • 1 slides

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