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Understanding Enzyme Inhibitors in Medicinal Science

Learn about how enzyme inhibitors affect neurotransmitters like noradrenaline and substrates like angiotensin I, impacting heart health and blood pressure regulation. Discover their role in preventing heart attacks and strokes. Dive into the research on ACE inhibitors and their potential benefits.

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Understanding Enzyme Inhibitors in Medicinal Science

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  1. SL MD4 Enzyme inhibitors as medicines

  2. Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to heart muscles Increases heart beat Bad for heart Antagonist (propanolol) blocks receptor site Angiotensin I (substrate) Fits into active site of enzyme (ACE) Changes it to angiotensin II Increases blood pressure Causes heart attacks and strokes ACE inhibitor (captopril) blocks active site A bit like the antagonists!

  3. What causes the high blood pressure? Need enzyme inhibitor ACE - Angiotensin Converting Enzyme angiotensin I  angiotensin II + dipeptide Inactive Active – causes high blood pressure

  4. Following the lead But proteins are digested in the stomach Venom of Brazilian Arrowhead Viper can kill by lowering blood pressure It contained several proteins which were ACE inhibitors

  5. Try Ass 9.

  6. Back to the lead compounds .. Active proteins from snake venom had the amino acid proline at the COOH end of the chain.

  7. After synthesising hundreds of compounds with proline in … Not a protein so can be taken orally!

  8. Try Ass 10.

  9. Noradrenaline (neurotransmitter) Fits into receptor site Electrical impulse sent to heart muscles Increases heart beat Bad for heart Antagonist (propanolol) blocks receptor site Angiotensin I (substrate) Fits into active site of enzyme (ACE) Changes it to angiotensin II Increases blood pressure Causes heart attacks and strokes ACE inhibitor (captopril) blocks active site A bit like the antagonists!

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